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Safety Information

S-025

Supelco

JWH-018 solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C24H23NO
CAS Number:
209414-07-3
Molecular Weight:
341.45
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology
forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3

InChI key

JDNLPKCAXICMBW-UHFFFAOYSA-N

Related Categories

General description

JWH-018 is a synthetic cannabinoid found in several versions of the herbal mixture “Spice.” Illicit use of this Spice cannabinoid centers on its psychoactive effects which mimic those of Δ9-THC in cannabis. While considerably more potent than similar amounts of cannabis, JWH-018 also presents significant challenges for detection by typical Δ9-THC testing assays.
In July, 2009, the US Drug Enforcement Agency (DEA) listed JWH-018 on its Drugs and Chemicals of Concern list. In addition to reported seizures of Spice in Ohio and Florida, several states have passed legislative action restricting the sale or possession of JWH-018 including Alabama, Arkansas, Georgia, Kansas, Kentucky, North Dakota, and Tennessee.

Application


  • Investigating Synthetic Cannabinoids in Leukemia: A study exploring the effects of synthetic cannabinoids like JWH-018 on leukemia and leukemic stem cells offers insights into potential therapeutic applications. This research highlights the value of JWH-018 as a tool for understanding cancer pathogenesis and developing new treatments, reinforcing its significance in biomedical research (Salcin et al., 2024).

    • Yeast Biosensor for Cannabinoid Detection: Research on a GPCR-based yeast biosensor for point-of-use cannabinoid determination, including synthetic cannabinoids such as JWH-018, showcases innovative biotechnological applications. This study demonstrates the biosensor′s utility in biomedical and environmental monitoring, potentially influencing drug safety and public health strategies (Miettinen et al., 2022).

    • Molecular Signaling of Synthetic Cannabinoids: A comparative study on the molecular signaling of synthetic cannabinoids, including JWH-018, provides critical data on their effects on CB1 and CB2 receptors. This research is pivotal for pharmacological studies aiming to understand the complex interactions of these compounds at the molecular level, thereby aiding in the development of targeted therapies for various conditions (Andersen et al., 2021).

    • Enhancing Drug Analysis Sensitivity: A study aimed at enhancing the nonfouling properties and sensitivity of Surface-Enhanced Raman Scattering (SERS) substrates for potent drug analysis, including JWH-018, highlights its application in forensic science. This research contributes to more accurate and rapid detection methods, essential for effective law enforcement and therapeutic monitoring (Masterson et al., 2021).




Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

Product No.
Description
Pricing

related product

Product No.
Description
Pricing

S-041

Spice Cannabinoid Mix 2 solution, 100 μg/mL each component in acetonitrile, ampule of 1.0 mL, certified reference material, Cerilliant®

S-038

Spice Cannabinoid Mix solution, 100 μg/mL each component in acetonitrile, ampule of 1.0 mL, certified reference material, Cerilliant®

S-033

JWH-018 5-Pentanoic acid metabolite solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

S-035

JWH-018 4-Hydroxypentyl metabolite solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

S-039

JWH-018 4-Hydroxypentyl metabolite-D5 (indole-D5) solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

06693

Timestrip Plus™ -20 °C

S-106

JWH-018 5-Pentanoic acid beta-D-glucuronide solution, 100 μg/mL (Acetonitrile:Water (90:10) (v/v)), certified reference material, ampule of 1 mL

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 2

Flash Point(F)

49.5 °F

Flash Point(C)

9.7 °C

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Articles

Impact of Mobile Phase Additives on LC-MS Sensitivity, Demonstrated using Spice Cannabinoids

This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.

Synthetic Cannabinoid Analysis

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

Chromatograms

application for HPLCapplication for HPLCapplication for HPLC

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