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Merck
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Safety Information

S-011

Supelco

Sibutramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Sibutramine hydrochloride monohydrate, 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil

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About This Item

Empirical Formula (Hill Notation):
C17H26ClN · HCl
CAS Number:
84485-00-7
Molecular Weight:
316.31
EC Number:
200-659-6
MDL number:
MFCD04039806
UNSPSC Code:
41116107
PubChem Substance ID:
329824413
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

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D8375

D-2-脱氧葡萄糖

D-2-脱氧葡萄糖 ≥98% (GC), BioXtra

D3179

D-2-脱氧葡萄糖

甲基α-D-吡喃葡萄糖苷 ≥99% (GC)

M9376

甲基α-D-吡喃葡萄糖苷

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, inhibition assay: suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

assay

≥99% (GC)

assay

≥98% (GC)

assay

≥98% (GC)

assay

≥99% (GC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: soluble 330 mg/mL, clear, colorless

solubility

H2O: 0.250 g/5mL

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

water: 50 mg/mL, clear, colorless

form

crystalline

form

crystalline

form

powder

form

powder

General description

Sibutramine, a SNRI and anorectant, was marketed as a treatment for obesity until 2010 when it was removed from the market over concerns of potential adverse cardiovascular side effects. Sold under trade names Reductil, Meridia®, and Subitrex, this sibutramine Snap-N-Spike® reference solution is applicable for use in LC/MS or GC/MS applications for clinical toxicology and forensic analysis.

Biochem/physiol Actions

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI).
Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Meridia is a registered trademark of Abbott Laboratories Corp.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Information

监管及禁止进口产品
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    Mohamed-I Kotb El-Sayed et al.
    BMC complementary medicine and therapies, 20(1), 290-290 (2020-09-25)
    Diabetes and its related complications remain to be a major clinical problem. We aim to investigate the antidiabetic mechanistic actions of Plicosepalus Acaciae (PA) flowers in streptozotocin (STZ)-induced diabetic rats. After diabetes induction, rats were divided randomly into five groups

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