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N-107

Supelco

Norhydromorphone hydrochloride solution

1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C16H18ClNO3
CAS Number:
14140-35-3
Molecular Weight:
307.77
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

Related Categories

General description

A long-term urinary metabolite of hydromorphone, a very potent opioid analgesic marketed under brand names including Palladone and Dilaudid. Hydromorphone is often used medicinally as an alternative to morphine for treatment of pain or as a cough suppressant for painful coughing resulting from continued bronchial irritation. This certified reference standard is suitable for use as a starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis, clinical toxicology, and pain prescription monitoring to urine drug testing and pharmaceutical research.

Application

  • Bifunctional opioid properties: Research on Norhydromorphone demonstrates its potential as a bifunctional opioid with intriguing effects due to substitutions in the N-Phenethyl moiety. This investigation into its unique properties can advance understanding of opioid receptor interactions, relevant to drug development and pain management strategies (Wang et al., 2020).
  • Opioid metabolite detection: Norhydromorphone, identified as a significant opioid metabolite, is crucial for studies using exhaled breath condensate (EBC) techniques. This method, applicable in pharmaceutical research, aids in non-invasive monitoring and analyzing opioid consumption and metabolism (Borras et al., 2019).
  • Capillary electrophoresis in metabolism studies: The use of capillary electrophoresis to study Norhydromorphone metabolism offers a precise analytical method, enhancing the biochemical assay capabilities in opioid pharmacology research (Baldacci and Thormann, 2006).
  • Antinociceptive activities: Identification and synthesis of Norhydromorphone were followed by evaluation of its antinociceptive activities using the rat formalin test. This research contributes to understanding its potential as an opioid analgesic in pain management (Zheng, McErlane, and Ong, 2004).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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H-004

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H-049

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H-050

Hydromorphone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-051

Hydromorphone-3-β-D-glucuronide, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

N-110

Norhydromorphone-D3 hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 2

Flash Point(F)

49.5 °F

Flash Point(C)

9.7 °C

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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