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N-006

Supelco

Normorphine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C16H17NO3
CAS Number:
466-97-7
Molecular Weight:
271.31
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

2-8°C

SMILES string

O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3)c45

InChI

1S/C16H17NO3/c18-11-3-1-8-7-10-9-2-4-12(19)15-16(9,5-6-17-10)13(8)14(11)20-15/h1-4,9-10,12,15,17-19H,5-7H2/t9?,10-,12+,15+,16+/m1/s1

InChI key

ONBWJWYUHXVEJS-YTPBOXJFSA-N

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General description

Normorphine is a primary urinary metabolite of the opiate analgesic morphine. This Snap-N-Spike® reference solution is applicable for use in LC/MS or GC/MS applications such as pain prescription monitoring, urine drug testing, clinical toxicology, or forensic analysis. Morphine, used to relieve both acute and chronic severe pain is known under trade names MS Contin®, Kadian®, Oramorph®, and Roxanol.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Kadian is a registered trademark of Actavis Elizabeth LLC
MS Contin is a registered trademark of Purdue Frederick Company
Oramorph is a registered trademark of AAIPharma, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Dihydromorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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IMPM-005-06

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Morphine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-005

Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Morphine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Morphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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M-086

Morphine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-120

Morphine-6-β-D-glucuronide-D3 solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

WGK

WGK 2

Flash Point(F)

49.5 °F

Flash Point(C)

9.7 °C

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Pawula et al.
Journal of pharmaceutical and biomedical analysis, 11(4-5), 401-406 (1993-04-01)
A new, simple and rapid extraction procedure coupled with a combined coulometric-fluorescence HPLC assay is described for the simultaneous determination of morphine (M) and morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), and normorphine (NM) in plasma. The effect of concentration and pH of
J Hasselström et al.
Pharmacology & toxicology, 79(1), 40-46 (1996-07-01)
Morphine, morphine-6-glucuronide and normorphine were administered to male Sprague-Dawley-rats. Analgesic effect was estimated with the hot plate and spinal nociceptive reflex depression. After intraperitoneal administration the molar potency ratio of morphine-6-glucuronide/morphine was 1.7 estimated by the paw lick latency on
O Dale et al.
European journal of clinical pharmacology, 63(9), 837-842 (2007-07-11)
To compare the time course of morphine and metabolite concentrations in serum and cerebrospinal fluid (CSF) after intravenous and intramuscular administration after surgery. This was a randomized double-blind, double-dummy study in patients who had undergone hip replacement surgery. Morphine (M
A A Coutts et al.
Canadian journal of physiology and pharmacology, 76(3), 340-346 (1998-07-23)
Cannabinoid receptor agonists inhibit electrically evoked isometric contractions of the myenteric plexus--longitudinal muscle preparation of the guinea-pig small intestine (MPLM), probably by reducing release of acetylcholine (ACh) through the activation of prejunctional CB1 receptors. As CB1 receptors are thought to
A Z Rónai et al.
Neuropeptides, 25(2), 127-129 (1993-08-01)
The kinetic parameters of antagonism by the delta opioid receptor selective antagonist N-t-Boc-Tyr-Pro-Gly-Phe-Leu-Thr, obtained by using moderately selective or selective agonists, were compared in the mouse vas deferens bioassay. The apparent affinity for the preferred receptor type was 6.8 times
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