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Safety Information

M-920

Supelco

Maprotiline hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C20H24ClN
CAS Number:
10347-81-6
Molecular Weight:
313.86
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24

InChI

1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H

InChI key

NZDMFGKECODQRY-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530)

Related Categories

General description

Maprotiline is a tetracyclic antidepressant marketed under the trade name Ludiomil for treatment of depression.  This Certified Spiking Solution® suitable for use in urine drug testing, clinical toxicology, or forensic analysis by LC-MS/MS or GC/MS.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Edward C Lauterbach et al.
The Journal of neuropsychiatry and clinical neurosciences, 22(1), 8-18 (2010-02-18)
This manuscript reviews the preclinical in vitro, ex vivo, and nonhuman in vivo effects of psychopharmacological agents in clinical use on cell physiology with a view toward identifying agents with neuroprotective properties in neurodegenerative disease. These agents are routinely used
Suzanne M Cloonan et al.
Leukemia & lymphoma, 51(3), 523-539 (2010-02-10)
The discovery that some selective serotonin transporter- (SSRI) and norepinephrine transporter- (NSRI) targeting antidepressants have the potential to act as anticancer agents adds greatly to their diverse pharmacological application. We report that the SSRI fluoxetine and the NSRI maprotiline are
Su-Hyun Jo et al.
Archives of pharmacal research, 30(4), 453-460 (2007-05-11)
Maprotiline, an atypical antidepressant, can induce prolonged QT and torsades de pointes. We studied the effects of maprotiline on human ether-a-go-go-related gene (HERG) channels expressed in Xenopus oocytes and HEK293 cells. Maprotiline induced a concentration-dependent decrease in current amplitudes at
V Hajhashemi et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(12), 1053-1059 (2010-06-25)
To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema. Male Wistar rats were used. Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg(-1)) was assessed using a paw edema
Vera L A Pettersen et al.
Anesthesia and analgesia, 109(4), 1312-1317 (2009-09-19)
Antidepressant drugs act as potent inhibitors of norepinephrine and/or serotonin reuptake and are widely used with opioids for the treatment of chronic pain. The mechanism of this increased analgesic action is unclear. We compared the antinociceptive effects of the intrathecal
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