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Merck
CN

M-132

MSTFA Reagent

ampule of 10 × 1.2 mL, analytical standard, Cerilliant®

Synonym(s):

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329817869
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411

Key Documents

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Product Name

MSTFA Reagent, ampule of 10 × 1.2 mL, analytical standard, Cerilliant®

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

grade

analytical standard

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

packaging

ampule of 10 × 1.2 mL

manufacturer/tradename

Cerilliant®

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

application(s)

forensics and toxicology

format

neat

storage temp.

−20°C

Quality Level

100

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Application

MSTFA reagent may be used as a derivatizing agent in the following:
  • Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2), and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
  • Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).

Features and Benefits

  • Very volatile of TMS-acetamides.
  • More volatile than BSA or BSTFA but with similar silylation strength.
  • Useful in the analysis of volatile trace materials.
  • Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.

General description

MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

Regulatory Information

危险化学品
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Analysis of trenbolone acetate metabolites and melengestrol in environmental matrices using gas chromatography--tandem mass spectrometry
Parker AJ, et al.
Talanta, 99(3), 238-246 (2012)
The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography?mass spectrometry based metabolomics
Khakimov B, et al.
Analytical and Bioanalytical Chemistry, 405(3), 9193-9205 (2013)
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry
Sebok A, et al.
Talanta, 76(3), 642-650 (2008)
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
John A Bowden et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3237-3242 (2009-08-21)
Steroid derivatization was investigated by varying the experimental parameters (reagent, reaction time, and reaction temperature) to determine the optimal conditions for individual steroids, and for larger subsets. Three methods of derivatization enhancement were also investigated: the use of sonication, the
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