M-031
Morphine-3-β-D-glucuronide solution
1 mg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®
About This Item
grade
certified reference material
Quality Level
form
liquid
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
drug control
Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
concentration
1 mg/mL in methanol with 0.05% NaOH
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
2-8°C
SMILES string
O[C@@H](C=C1)[C@H]2[C@](C1[C@H]3C4)(CCN3C)C5=C4C=CC(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O6)=C5O2
InChI
1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10?,11-,12+,15+,16+,17-,19+,20+,22-,23+/m1/s1
InChI key
WAEXKFONHRHFBZ-RURUVCMVSA-N
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General description
Application
- Morphine-3-β-ᴅ-glucuronide (M3G) Solution in Clinical Analysis: The use of M3G glucuronide standard in liquid chromatography-tandem mass spectrometry has been validated for quantifying analgesics and sedatives in human plasma, with applications in intensive care and neurological death determination studies. This underlines the solution′s critical role in pharmacokinetic research of morphine metabolites within pharmaceutical sciences (Jutras et al., 2020).
- Opioid Metabolite Research with M3G: Analysis of opiate and opiate metabolites, including M3G, in urine after consumption of cold syrups by LC-MS/MS, emphasizes the solution′s importance in biochemical assays of morphine derivatives. This research is integral for monitoring drug abuse and optimizing therapeutic strategies in the pharma and biotech sectors (Yen YT et al., 2020).
- Electrophoresis-based Determination of M3G: Capillary electrophoresis-mass spectrometry has determined morphine and its isobaric glucuronide metabolites, including M3G, as an essential biochemistry tool for studying opioid metabolism. Such methods enable accurate profiling of drug metabolism, serving both research and clinical diagnostic purposes (Isbell TA et al., 2015).
- M3G Metabolism and UGT2B7 Enzyme: The catalysis of M3G glucuronidation and glucosidation by UDP-glucuronosyltransferase 2B7 highlights the solution′s use in uncovering complementary metabolic pathways of morphine. The findings have significant implications for the biochemist′s understanding of drug metabolism pathways in pharmaceutical research (Chau N et al., 2014).
- Stability Assessment in Sewage Epidemiology: The stability of drug biomarkers, including M3G in municipal wastewater, influences the estimation of drug consumption. Using high-purity M3G solution as a research standard aids in sewage epidemiology and environmental monitoring (Senta I et al., 2014).
Legal Information
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes,Central nervous system
WGK
WGK 2
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Regulatory Information
Certificates of Analysis (COA)
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Protocols
Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.
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