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H-081

Supelco

7-Hydroxyquetiapine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H25N3O3S
CAS Number:
139079-39-3
Molecular Weight:
399.51
MDL number:
MFCD09260019
UNSPSC Code:
41116107
PubChem Substance ID:
329815136
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

OCCOCCN1CCN(C2=NC(C=CC(O)=C3)=C3SC4=C2C=CC=C4)CC1

InChI

1S/C21H25N3O3S/c25-12-14-27-13-11-23-7-9-24(10-8-23)21-17-3-1-2-4-19(17)28-20-15-16(26)5-6-18(20)22-21/h1-6,15,25-26H,7-14H2

InChI key

VEGVCHRFYPFJFO-UHFFFAOYSA-N

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General description

A Certified Solution Standard for the primary active metabolite of quetiapine, marketed as the atypical antipsychotic Seroquel® for the treatment of depression, bipolar disorder, and schizophrenia. This new reference standard is suitable for a variety of GCMS and LCMS applications from forensic and forensic toxicology analyisis to urine drug testing. We also offer certified Snap-N-Shoot® solutions of the parent drug Quetiapine fumarate (Q-001) and the internal standard Quetiapine-D8 hemifumarate (Q-002) as well as a wide selection of other atypical antipsychotics and their metabolites and internal standards, such as aripiprazole, clozapine, risperidone, olanzapine, and ziprasidone.

Application


  • Metabolic Analysis of Quetiapine and 7-Hydroxyquetiapine: Research outlined a liquid chromatographic-mass spectrometric procedure specifically developed for analyzing 7-Hydroxyquetiapine alongside quetiapine, validating the method through its application in rat brain and blood samples. This study emphasizes the value of 7-Hydroxyquetiapine in understanding the pharmacokinetics of antipsychotic treatments, crucial for drug metabolism research and therapeutic monitoring (Heisel et al., 2024).

  • Drug Entry and Retention in Hair: An investigative study focused on the distribution of Quetiapine and 7-Hydroxyquetiapine in guinea pig hair roots and shafts post-repeated administration. This work contributes to forensic toxicology by exploring how antipsychotic drugs and their metabolites interact with and are retained in hair, providing insights that support legal and medical inquiries into drug use history (Ji et al., 2021).

  • Single Dose Metabolite Tracking: Research examined the characteristics of quetiapine and 7-Hydroxyquetiapine in hair roots and blood after a single dose, offering a detailed look at the acute phase of metabolite processing in the body. This study aids in forensic analysis and may contribute to better understanding the immediate metabolic responses to quetiapine in clinical scenarios (Yan et al., 2020).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Seroquel is a registered trademark of Astrazeneca UK
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R H Pullen et al.
Journal of chromatography, 573(1), 49-57 (1992-01-03)
ICI 204,636 (I) is an orally active antipsychotic agent under development for the treatment of schizophrenia in humans. It is partially converted in animals to an active 7-hydroxy metabolite (II). Methods were developed for the simultaneous determination of both analytes

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