H-052
4′-Hydroxydiclofenac solution
100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
About This Item
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
100 μg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
OC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl
InChI
1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)
InChI key
KGVXVPRLBMWZLG-UHFFFAOYSA-N
General description
Application
- Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs): This study examines the biotransformation of 4′-Hydroxydiclofenac by Streptomyces griseolus CYP105A1, emphasizing its relevance in pharmacokinetic research on drug metabolism and enzyme inhibition studies (Yogo et al., 2022).
- A multi-biomarker approach to assess toxicity of diclofenac and 4-OH diclofenac: Investigates the environmental impact of 4′-Hydroxydiclofenac on molluscs, providing insights into the ecological side-effects of pharmaceutical residues and their metabolites, important for researchers studying drug metabolism and environmental safety (Swiacka et al., 2022).
- Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish: Highlights the role of 4′-Hydroxydiclofenac in early developmental stages of liver metabolism in zebrafish, useful for developmental pharmacokinetics and toxicology studies (Nawaji et al., 2020).
- Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4′- and 5-Hydroxylations: Explores the specific roles of cytochrome P450 enzymes in the metabolism of diclofenac and its major metabolite 4′-Hydroxydiclofenac, offering critical insights for pharmacokinetic research and drug metabolism assays (Miura et al., 2020).
Legal Information
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
Flash Point(F)
35.6 °F
Flash Point(C)
2 °C
Regulatory Information
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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