Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

D-055

Supelco

N-Desethylamiodarone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Sign Into View Organizational & Contract Pricing
All Photos(1)
Empirical Formula (Hill Notation):
C23H26ClI2NO3
CAS Number:
96027-74-6
Molecular Weight:
653.72
EC Number:
200-659-6
MDL number:
MFCD08060094
UNSPSC Code:
41116107
PubChem Substance ID:
329798619
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

IC1=CC(C(C2=C(CCCC)OC3=CC=CC=C23)=O)=CC(I)=C1OCCNCC.Cl

InChI

1S/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2;/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3;1H

InChI key

OCQPMJVGWGJLLG-UHFFFAOYSA-N

Related Categories

General description

A Certified Spiking Solution® for use in therapeutic drug monitoring analyses by HPLC or LCMS. N-Desethylamiodarone is the primary, active metabolite of amiodarone, an antiarrhythmic agent marketed as Pacerone®, Cordarone®, Aratac, and Atlansil and monitored by clinical labs to ensure patients remain within the drugs therapeutic range.

Application


  • Impact on Amiodarone Absorption: A study examining the effects of probiotics on drug pharmacokinetics demonstrated that E. coli Nissle 1917 alters the absorption of amiodarone in rats, which suggests implications for N-Desethylamiodarone hydrochloride, a metabolite of amiodarone, in similar biochemical studies. This provides valuable insights for research into the metabolic pathways and interactions of amiodarone derivatives (Matuskova et al., 2014).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Cordarone is a registered trademark of Sanofi S.A.
Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

Product No.
Description
Pricing

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Melissa K Passarelli et al.
Analytical chemistry, 87(13), 6696-6702 (2015-05-30)
Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was used to investigate the cellular uptake of the antiarrhythmic agent amiodarone, a phospholipidosis-inducing

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service