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Safety Information

C-175

Supelco

Caffeine Impurity Mixture solution

0.04-2.0 mg/mL (50:50 Acetonitrile:Water (v/v)), certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C7H8N4O2
Molecular Weight:
180.16
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

composition

Caffeine
Caffeine
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride, 2 mg/mL
1,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dione(Caffeine Imp F)
Theobromine (Caffeine RCD)
Caffeine
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride, 40 μg/mL
Theobromine (Caffeine Imp D)
Theobromine (Caffeine RCD)
Caffeine
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride, 40 μg/mL
Theophylline (Caffeine Imp A)
Caffeine
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride, 40 μg/mL
1,3,9-Trimethyl-3,9-dihydro-1H-purine-2,6-dione(Caffeine Imp C)
Caffeine
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride
2-(Tert-Butylamino)-3′-Bromopropiophenone Hydrochloride, 40 μg/mL

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

0.04-2.0 mg/mL (50:50 Acetonitrile:Water (v/v))

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

multi-component solution

storage temp.

−20°C

General description

Caffeine is a naturally occurring compound that is reported to be found in about 60 plant species. It is consumed in different forms such as coffee, tea, cacao powder, and other food and beverages. It is an ergogenic aid because of its ability to enhance the mental and physical performance of athletes during training and competitions. It has been shown to exhibit structural similarities to adenosine and therefore acts by inhibiting the adenosine receptors located on the cell membranes and blocking their activity. It also raises the level of adrenaline in the body which leads to the ergogenic action.

Application

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H225,H302,H319,H360D

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

48.2 °F

Flash Point(C)

9 °C

Regulatory Information

监管及禁止进口产品

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Caffeine and exercise
Graham TE
Sports Medicine (Auckland, N.Z.), 31(11), 785-807 (2001)
Caffeine consumption
Barone JJ and Roberts HR
Food And Chemical Toxicology, 34(1), 119-129 (1996)
Caffeine and adenosine
Ribeiro JA and Sebastiao AM
Journal of Alzheimer'S Disease, 20(s1), S3-S15 (2010)
Caffeine
USP42-NF37
United States Pharmacopeia/National Formulary, 34(5), 645-645 (2018)

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