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C-017

Supelco

(±)-Cotinine-d3 solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

(+/-)-Cotinine-d3 solution

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About This Item

Empirical Formula (Hill Notation):
C10H9D3N2O
CAS Number:
110952-70-0
Molecular Weight:
179.23
EC Number:
200-659-6
MDL number:
MFCD00083283
UNSPSC Code:
41116107
PubChem Substance ID:
329774766
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/i1D3

InChI key

UIKROCXWUNQSPJ-FIBGUPNXSA-N

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Related Categories

General description

Cotinine is an alkaloid found in tobacco as well as a major urinary metabolite of nicotine. This stable-labeled internal standard is suitable for quantitation of cotinine levels in urine, blood, and saliva for GC/MS or LC-MS/MS applications in nicotine testing or clinical and diagnostic testing of nicotine biomarkers.

Application



  • Advanced mass spectrometry applications: A review covers high-performance liquid chromatography-mass spectrometry (HPLC-MS) methods, including the use of (±)-Cotinine-d₃ for the analysis of nicotine and its metabolite cotinine across various biological matrices, highlighting its role in accurate biomarker quantification (Jin et al., 2022).


  • Exposure assessment in passive smoking: The study employs stable isotope dilution gas chromatography-triple quadrupole mass spectrometry with (±)-Cotinine-d₃ to determine urinary cotinine levels in children exposed to passive smoking, demonstrating its efficacy in environmental health research (Wang et al., 2014).


  • Nicotine metabolism in special populations: Research utilizes a liquid chromatography-tandem mass spectrometry method to investigate nicotine metabolism in HIV-1-positive smokers, using (±)-Cotinine-d₃ to track metabolic variations, thereby aiding in personalized medicine approaches (Earla et al., 2014).


  • Automated LC-MS-MS for cotinine detection: The development of an automated solid-phase extraction method for LC-MS-MS highlights the use of (±)-Cotinine-d₃ for streamlined and precise cotinine detection, applicable in clinical toxicology and therapeutic monitoring (Dunlop et al., 2014).


  • Quantitative analysis in smoking cessation: A sensitive UPLC-tandem mass spectrometry procedure quantifies nicotine, cotinine, and their metabolites in plasma using (±)-Cotinine-d₃ as an internal standard, crucial for clinical studies on smoking cessation (Dobrinas et al., 2011).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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