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A-907

Supelco

alpha-Hydroxyalprazolam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C17H13ClN4O
CAS Number:
37115-43-8
Molecular Weight:
324.76
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12

InChI

1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2

InChI key

ZURUZYHEEMDQBU-UHFFFAOYSA-N

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General description

A major urinary metabolite of the benzodiazepine alprazolam. Alprazolam, commonly sold under the trade name Xanax®, is a short-acting anxiolytic approved to treat panic and other anxiety disorders including generalized or social anxiety disorder. This certified Snap-N-Spike® solution standard is suitable for use in LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.

Application


  • Application of chemometric approach for development and validation of high performance liquid chromatography method for estimation of ropinirole hydrochloride.: This study employs the LiChrospher® 100 RP-18 endcapped (5 µm) column for the estimation of ropinirole hydrochloride, showcasing its efficacy in the development of a robust HPLC method. The chemometric approach enhances method development and validation, demonstrating high precision and accuracy (Fatima et al., 2019).

  • Rapid, highly sensitive method for the determination of morphine and its metabolites in body fluids by liquid chromatography-mass spectrometry.: Utilizing the LiChrospher® 100 RP-18 endcapped (5 µm) column, this study develops a highly sensitive LC-MS method for detecting morphine and its metabolites in body fluids, underscoring the column′s capability in bioanalytical applications (Schänzle et al., 1999).



Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
LiChrospher is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Xanax is a registered trademark of Pharmacia & Upjohn Company

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Description
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A-902

Alprazolam-d5 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-903

Alprazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-904

alpha-Hydroxyalprazolam-d5 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-908

alpha-Hydroxyalprazolam-d5 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-910

Alprazolam-d5 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

B-033

Benzodiazepine Multi-component Mixture-8 solution, 250 μg/mL each component in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

IMF-020S

iMethod Test Kit for Benzodiazepines with Synthetic Urine, kit of 23 × 1.0 mL ampules, certified reference material, Cerilliant®

H-142

4-Hydroxyalprazolam solution, 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

H-143

4-Hydroxyalprazolam-D5 solution, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

WGK

WGK 2

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Annika Allqvist et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 814(1), 127-131 (2004-12-21)
A sensitive and specific method was developed for quantification of alprazolam and its two metabolites 4-hydroxyalprazolam and alpha-hydroxyalprazolam in plasma. The work up procedure was solid phase extraction. Liquid chromatography-mass spectrometry (LC-MS) was used for separation, detection and quantification of
A J Jenkins et al.
Journal of analytical toxicology, 21(3), 218-220 (1997-05-01)
Alprazolam is one of the most widely prescribed benzodiazepines in the United States. It is generally considered a safe and effective drug for the treatment of anxiety disorders and panic attacks. Few overdoses that are due to the sole ingestion
Alprazolam, alpha-hydroxy- and 4-hydroxyalprazolam analysis in plasma by high-performance liquid chromatography.
R L Miller et al.
Journal of chromatography, 430(1), 180-186 (1988-08-19)
V D Schmith et al.
Journal of clinical pharmacology, 31(6), 571-579 (1991-06-01)
In a double-blind, randomized, placebo-controlled study, the pharmacokinetics of alprazolam and its active metabolite, alpha-hydroxyalprazolam, were determined in 12 normal subjects and 12 dialysis patients [7 hemodialysis (HD) patients and 5 continuous ambulatory peritoneal dialysis (CAPD) patients]. Blood samples were
K M Höld et al.
Journal of mass spectrometry : JMS, 31(9), 1033-1038 (1996-09-01)
A sensitive and specific method was developed for the determination of alprazolam and its major metabolite alpha-hydroxyalprazolam in plasma. After the addition of deuterium-labeled internal standards, plasma samples were buffered to pH 9 with 1 ml of saturated sodium borate
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