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A-134

Supelco

Acetaminophen (Paracetamol) Impurity Mixture solution

25 μg/mL in methanol (each analyte), certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

UNSPSC Code:
12352200

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

25 μg/mL in methanol (each analyte)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

multi-component solution

storage temp.

−20°C

General description

Acetaminophen is formed as a metabolic product of phenacetin and is a well-known drug used in the treatment of pain and fever due to its effective central analgesic and antipyretic properties. It is also the only analgesic drug that is non-opioid and available in the oral, rectal, and intravenous formulation forms. It has been posited to inhibit the synthesis of prostaglandins and exhibit a mode of action similar to nonsteroidal anti-inflammatory drugs (NSAIDs).

Application

Acetaminophen Impurity Mixture solution may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Analyte

Description
    Acetaminophen Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material
    Acetaminophen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material
    Acetaminophen Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material
    Acetaminophen Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material
    Acetaminophen, Pharmaceutical Secondary Standard; Certified Reference Material

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Information

监管及禁止进口产品

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Acetaminophen poisoning and toxicity
Rumack BH and Matthew H
Pediatrics, 55(6), 871- 876 (1975)
Intravenous paracetamol (acetaminophen)
Duggan ST and Scott LJ
Drugs, 69(1), 101- 113 (2009)
Paracetamol (Acetaminophen): mechanisms of action
Anderson BJ
Pediatric Anesthesia, 18(10), 915- 921 (2008)
Acetaminophen-induced hepatotoxicity
James LP, et al.
Drug Metabolism and Disposition, 31(12), 1499- 1506 (2003)
Acetaminophen
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 39(6), 40-40 (2018)

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