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Merck
CN

A-096

Aldosterone solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Aldosterone, 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X

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About This Item

Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
52-39-1
Molecular Weight:
360.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329770641
EC Number:
200-835-2
Beilstein/REAXYS Number:
3224996
MDL number:
MFCD00051136

Key Documents

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Product Name

Aldosterone solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI key

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

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Application

The d-isomer of aldosterone is considered to be the biologically active isomer.

General description

Aldosterone is a hormone in the mineralocorticoid family which stimulates sodium transport across cell membranes and assists in the maintenance of blood pressure and blood volume. Aldosterone levels in serum/plasma and urine are measured by LC-MS/MS for investigation of primary or secondary aldosteronism ranging from adrenal cortical hyperplasia to renovascular disease and Bartter′s syndrome.

Other Notes

Exists as an equilibrium mixture of the aldehyde and the hemiacetal.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

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Carine Gennari-Moser et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 1111-1117 (2013-03-06)
Aldosterone levels are markedly elevated during normal pregnancy but fall even though volume contracts when preeclampsia occurs. The level of aldosterone in either condition cannot be explained solely by the activity of the renin-angiotensin II system. In normal gestation, vascular
Katy Sánchez-Pozos et al.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 64(6 Pt 1), 546-557 (2013-03-22)
The vascular endothelium is a dynamic tissue that is sensitive to physical and chemical stimuli. The fact that endothelial cells are directly exposed to the blood fluid components provides the ability to regulate diverse physiological functions, among them are: the
Teresa Duda et al.
Biochemistry, 52(13), 2337-2347 (2013-03-08)
ANF-RGC is the prototype membrane guanylate cyclase, both the receptor and the signal transducer of the hormones ANF and BNP. After binding them at the extracellular domain, it, at its intracellular domain, signals activation of the C-terminal catalytic module and
Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved?
Christian Delles et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 958-960 (2013-03-06)
Athina Markou et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1409-1416 (2013-03-09)
Primary aldosteronism (PA) is an established cause of hypertension, whereas high-normal serum aldosterone levels have been linked to an increased risk for hypertension. We aimed to define the post-fludrocortisone-dexamethasone suppression test (FDST) normal cutoff values of aldosterone and the aldosterone
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Protocols

LC/MS/MS Analysis of Steroid Hormones in Plasma

The conversion of clinical methods to LC/MS/MS offers advantages; however, is accompanied by a few limitations, notably interference effects from the endogenous sample matrix.

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