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LM1104

Avanti

17:0-14:1 PE

Avanti Polar Lipids LM1104, methanol solution

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Synonym(s):
1-heptadecanoyl-2-(9Z-tetradecenoyl)-sn-glycero-3-phosphoethanolamine
Empirical Formula (Hill Notation):
C36H70NO8P
CAS Number:
958763-89-8
Molecular Weight:
675.92
UNSPSC Code:
12352211
NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (LM1104-1EA)

manufacturer/tradename

Avanti Polar Lipids LM1104

concentration

~10 μg/mL (Refer to C of A for lot specific concentration.)

application(s)

lipidomics
metabolomics

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCCCCCCCCCCC)=O

General description

Phosphoethanolamine (PE) acts as a parent compound for phosphatidylcholine and phosphatidylethanolamine synthesis.

Application

17:0-14:1 PE or 1-heptadecanoyl-2-(9Z-tetradecenoyl)-sn-glycero-3-phosphoethanolamine has been used as an internal standard:
  • for lipid quantification using liquid chromatography-mass spectrometry (LC-MS)
  • for the detection of lipids by tandem mass spectrometry (MS/MS) (related to lipidome analyses)
  • in lipid extraction using MTBE protocol

Biochem/physiol Actions

Phosphoethanolamine (PE) is known to show extensive antitumor action and prevents tumor proliferation, in vivo. Synthetic PE inhibits lung metastasis.

Packaging

2 mL Amber Glass Sealed Ampule (LM1104-1EA)

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 2

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mathieu Frechin et al.
Nature, 523(7558), 88-91 (2015-05-27)
Cells sense the context in which they grow to adapt their phenotype and allow multicellular patterning by mechanisms of autocrine and paracrine signalling. However, patterns also form in cell populations exposed to the same signalling molecules and substratum, which often
Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour
Frechin M. et al.
Nature, 523(7558), 88-91 (2015)
Kallol Gupta et al.
Nature protocols, 13(5), 1106-1120 (2018-04-28)
With the recent success in determining membrane protein structures, further detailed understanding of the identity and function of the bound lipidome is essential. Using an approach that combines high-energy native mass spectrometry (HE-nMS) and solution-phase lipid profiling, this protocol can
Ursula Loizides-Mangold et al.
Journal of lipid research, 53(8), 1522-1534 (2012-05-26)
Glycosylphosphatidylinositol (GPI) anchor biosynthesis takes place in the endoplasmic reticulum (ER). After protein attachment, the GPI anchor is transported to the Golgi where it undergoes fatty acid remodeling. The ER exit of GPI-anchored proteins is controlled by glycan remodeling and
A K Ferreira et al.
British journal of cancer, 109(11), 2819-2828 (2013-11-10)
We recently showed that synthetic phosphoethanolamine reduces tumour growth and inhibits lung metastasis in vivo. Here, we investigated its anti-leukaemia effects using acute promyelocytic leukaemia (APL) as a model. Cytotoxic effects of Pho-s on leukaemia cells were evaluated by MTT
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