890820P
Avanti
18:0 DAP
Avanti Research™ - A Croda Brand 890820P, powder
Synonym(s):
1,2-distearoyl-3-dimethylammonium-propane
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About This Item
Empirical Formula (Hill Notation):
C41H81NO4
CAS Number:
Molecular Weight:
652.09
UNSPSC Code:
12352211
NACRES:
NA.25
form
powder
packaging
pkg of 1 × 25 mg (890820P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 890820P
lipid type
transfection
cationic lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H]C(CN(C)C)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O
Application
1,2-distearoyl-3-dimethylammonium-propane (18:0 DAP) might be used to formulate lipid nanoparticles (LNPs) and to test its efficiency of packaging mRNA into an LNP. It might also be used in the preparation of “bubble liposomes” (BLs).
Biochem/physiol Actions
1,2-distearoyl-3-dimethylammonium-propane (18:0 DAP) is a cationic lipid and serves as a pH-sensitive transfection reagent.
Packaging
5 mL Clear Glass Sealed Ampule (890820P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Yoko Endo-Takahashi et al.
Biomaterials, 34(11), 2807-2813 (2013-01-25)
We have developed polyethyleneglycol (PEG)-modified liposomes (Bubble liposomes; BLs) that entrap ultrasound (US) contrast gas, and we have reported that the combination of BLs and US exposure was an effective tool for delivering pDNA and siRNA in vitro and in
Siddharth Patel et al.
Journal of controlled release : official journal of the Controlled Release Society, 303, 91-100 (2019-04-16)
Retinal gene therapy has had unprecedented success in generating treatments that can halt vision loss. However, immunogenic response and long-term toxicity with the use of viral vectors remain a concern. Non-viral vectors are relatively non-immunogenic, scalable platforms that have had
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