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About This Item
Empirical Formula (Hill Notation):
C59H116Cl5N7O4
CAS Number:
Molecular Weight:
1164.86
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
MVL5, Avanti Research™ - A Croda Brand 890000P, powder
Assay
>99% (TLC)
form
powder
packaging
package of 1 × 1 mg (890000P-1mg)
package of 1 × 5 mg (890000P-5MG)
manufacturer/tradename
Avanti Research™ - A Croda Brand 890000P
application(s)
advanced drug delivery
lipid type
transfection
cationic lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCC/C=C\CCCCCCCCOC1=C(OCCCCCCCC/C=C\CCCCCCCC)C=C(C(NCCNC(C([NH2+]CCC[NH3+])CCC[N+](CCC[NH3+])([H])CCC[NH3+])=O)=O)C=C1.[5Cl-]
Application
MVL5 has been used in liposome preparation.
Biochem/physiol Actions
MVL5 is a cationic lipid and is a pentavalent molecule. It is combined with 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOPC) in liposome formulation, for efficient gene transfection. It is considered less toxic.
Packaging
5 mL Amber Glass Screw Cap Vial (890000P-1MG)
5 mL Amber Glass Screw Cap Vial (890000P-5MG)
5 mL Amber Glass Screw Cap Vial (890000P-5MG)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
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Nathan F Bouxsein et al.
Biochemistry, 46(16), 4785-4792 (2007-03-30)
Small interfering RNAs (siRNAs) of 19-25 bp mediate the cleavage of complementary mRNA, leading to post-transcriptional gene silencing. We examined cationic lipid (CL)-mediated delivery of siRNA into mammalian cells and made comparisons to CL-based DNA delivery. The effect of lipid
Kai Ewert et al.
Journal of medicinal chemistry, 45(23), 5023-5029 (2002-11-01)
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. This paper describes the efficient and facile synthesis and the characterization of a new multivalent cationic lipid with a double-branched headgroup structure for
Polyamine Drug Discovery, 226-226 (2012)
Chia-Ling Chan et al.
The journal of gene medicine, 16(3-4), 84-96 (2014-04-23)
Cationic liposome (CL)-DNA complexes are promising gene delivery vectors with potential application in gene therapy. A key challenge in creating CL-DNA complexes for application is that their transfection efficiency (TE) is adversely affected by serum. In particular, little is known
Asymmetric cationic liposomes designed for heat-activated association with cells
Jing Y, et al.
Colloids and Surfaces. B, Biointerfaces, 151, 112-118 (2017)
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