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880400C

Avanti

16:0 PEG350 PE

Avanti Polar Lipids 880400C

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Synonym(s):
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] (ammonium salt)
CAS Number:
474922-84-4
UNSPSC Code:
12352211

form

liquid

packaging

pkg of 1 × 2.5 mL (880400C-25mg)
pkg of 2 × 4 mL (880400C-200mg)

manufacturer/tradename

Avanti Polar Lipids 880400C

concentration

10 mg/mL (880400C-25mg)
25 mg/mL (880400C-200mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[NH4+]

General description

16:0 PEG350 PE is a polyethylene glycol (PEG) conjugated phospholipid. It is a biopolymer with a molecular weight of 1075.4 Da.

Application

16:0 PEG350 PE is suitable for use in the preparation of Pdots and to differentiate based on shell′s composition. It might also be used in membrane preparation to study water dynamics.

Biochem/physiol Actions

Polyethylene glycol (PEG) conjugated phospholipids are useful in liposome formulation and are used as drug carriers. PEGylated lipids maintain the stereochemistry of liposomes. The formation of mixed micelles is supported by the use of highly concentrated PEG-lipids.

Packaging

5 mL Clear Glass Sealed Ampule (880400C-200mg)
5 mL Clear Glass Sealed Ampule (880400C-25mg)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Liver,Kidney, Respiratory system

WGK

WGK 3

Regulatory Information

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Eduardo M Clop et al.
The journal of physical chemistry. B, 118(23), 6150-6158 (2014-05-09)
The present work was aimed at studying the molecular dynamics at different levels of model membranes having a simulated glycoclix, with focus on the molecular crowding conditions at the lipid-water interfacial region. Thus, binary mixtures of dipalmitoylphosphatidylcholine (dpPC) and a
Pdots nanoparticles load photosensitizers and enhance efficiently their photodynamic effect by FRET
Haimov E, et al.
Royal Society of Chemistry Advances, 5(24), 18482-18491 (2015)
Sirkku Hanski et al.
Biomacromolecules, 11(12), 3440-3447 (2010-10-27)
We report on highly ordered oblique self-assemblies in ionic complexes of PEGylated triple-tail lipids and cationic polypeptides, as directed by side-chain crystallization, demonstrating also reversible oblique-to-hexagonal order-order transitions upon melting of the side chains. This is achieved in bulk by
Maria C Sandström et al.
Langmuir : the ACS journal of surfaces and colloids, 23(8), 4192-4198 (2007-03-09)
Polyethylene glycol (PEG)-conjugated lipids are commonly employed for steric stabilization of liposomes. When added in high concentrations PEG-lipids induce formation of mixed micelles, and depending on the lipid composition of the sample, these may adapt either a discoidal or a
G F Peacock et al.
Drug delivery, 10(1), 29-34 (2003-01-30)
A new cholesterol-carborane conjugate (BCH) has been synthesized as a potential targeting agent for boron neutron capture therapy (BNCT) of cancers. The compound is extremely water insoluble and was formulated in two liposomal formulations to determine if the compound could

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