880224P
Avanti
DSPE-PEG(5000) Maleimide
Avanti Polar Lipids 880224P, powder
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Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] (ammonium salt)
Recommended Products
form
powder
packaging
pkg of 1 × 5 mg (880224P-5mg)
manufacturer/tradename
Avanti Polar Lipids 880224P
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(CCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP([O-])(OCCNC([(OCH2CH2)113]NC(CCN1C(C=CC1=O)=O)=O)=O)=O.[NH4+]
Application
DSPE-PEG(5000) maleimide is suitable for the preparation of cationic liposomes for loading siRNA.. It has also been conjugated with Asn-Gly-Arg to prepare NLC (nanostructured lipid carrier).
Biochem/physiol Actions
Maleimide are useful in biomolecular conjugation. DSPE-PEG(5000) maleimide is used to prepare conjugated polymer nanoparticles.
Packaging
5 mL Amber Glass Screw Cap Vial (880224P-5mg)
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
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Catalysis of imido-group hydrolysis in a maleimide conjugate
Kalia J and Raines RT
Bioorganic & Medicinal Chemistry Letters, 17, 6286?6289-6286?6289 (2007)
Conjugated Polymers for Biological and Biomedical Applications, 29-29 (2018)
Yang Yang et al.
Biomaterials, 48, 84-96 (2015-02-24)
Tumor-oriented nanocarrier drug delivery approaches with photosensitivity have drawn considerable attention over the years. However, due to its low penetrability and ability to harm tissues, the use of UV light for triggered nanocarrier release in in vivo applications has been
Yanfang Yang et al.
Journal of pharmaceutical sciences, 104(4), 1328-1339 (2015-01-30)
A novel nanostructured lipid carrier (NLC) modified with photon-sensitive cell penetrating peptides (psCPP) and Asn-Gly-Arg (NGR) was designed to enhance paclitaxel (PTX)-targeted delivery and antitumor effect. The NGR moiety selectively binds to CD13-positive tumors. On other hand, the psCPP moiety
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