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880128P

Avanti

DSPE-PEG(2000) Amine

Avanti Polar Lipids

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Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt)
CAS Number:
474922-26-4
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (880128P-10mg)
pkg of 1 × 100 mg (880128P-100mg)
pkg of 1 × 25 mg (880128P-25mg)
pkg of 1 × 50 mg (880128P-50mg)
pkg of 1 × 500 mg (880128P-500mg)

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\N)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.

General description

DSPE-PEG(2000) is a 18-carbon acyl chain containing phospholipid with a critical micelle concentration of 1× 106 M. It is conjugated with functional groups like biotin, primary amine and carboxylic acid. The micelles display spheroid shape with a size of 18mm.

Application

DSPE-PEG(2000) Amine has been used:
  • for the generation of single-walled carbon nanotubes (SWNTs) phospholipid-polyethylene glycol-folic acid conjugate
  • in the preparation of polyethylene glycol (PEGylated) magnetic nanoparticles based liposomes
  • in the preparation of liposomes for myomerger ectodomain based disruption studies

Biochem/physiol Actions

DSPE-PEG(2000) micelles aids in the solubilization of hydrophobic drugs and their delivery. It is used for coating of magnetic iron oxide-based nanoparticles.

Packaging

20 mL Clear Glass Screw Cap Vial (880128P-500mg)
5 mL Amber Glass Screw Cap Vial (880128P-100mg)
5 mL Amber Glass Screw Cap Vial (880128P-10mg)
5 mL Amber Glass Screw Cap Vial (880128P-25mg)
5 mL Amber Glass Screw Cap Vial (880128P-50mg)

also commonly purchased with this product

Product No.
Description
Pricing

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thermodynamic and kinetic stability of DSPE-PEG (2000) micelles in the presence of bovine serum albumin
Kastantin M, et al.
The Journal of Physical Chemistry B, 114(39), 12632-12640 (2010)
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
Nitin N, et al.
Journal of Biological Inorganic Chemistry, 9(6), 706-712 (2004)
Myomaker and myomerger work independently to control distinct steps of membrane remodeling during myoblast fusion
Leikina E, et al.
Developmental Cell, 46(6), 767-780 (2018)
Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation
Ding H, et al.
Nanotechnology, 25(5), 055101-055101 (2014)
The impact of subcellular location on the near infrared-mediated thermal ablation of cells by targeted carbon nanotubes
Murali VS, et al.
Nanotechnology, 27(42), 425102-425102 (2016)
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