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Merck
CN

880126C

Avanti

DSPE-PEG(2000) Maleimide

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
474922-22-0
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

DSPE-PEG(2000) Maleimide, Avanti Research™ - A Croda Brand 880126C

InChI

1S/C53H94N3O57P.24C2H4.CH4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-51(60)66-45-47(71-52(61)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-70-114(63,64)69-42-39-55-53(62)65-43-44-68-73-75-77-79-81-83-85-87-89-91-93-95-97-99-101-103-105-107-109-11

InChI key

UJDWJEOGCPUOPU-VLQWDYIFSA-M

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\NC(CCN(C(C=C1)=O)C1=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2 mL (880126C-50mg)
pkg of 1 × 2.5 mL (880126C-25mg)
pkg of 1 × 4 mL (880126C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880126C

concentration

10 mg/mL (880126C-25mg)
25 mg/mL (880126C-100mg)
25 mg/mL (880126C-50mg)

shipped in

dry ice

storage temp.

−20°C

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Application

DSPE-PEG(2000) Maleimide has been used:
  • in the preparation of neutral liposome
  • in the preparation of immunoliposomes
  • to conjugate with P5 peptide to improve peptide incorporation into liposomes

Biochem/physiol Actions

Maleimide are useful in biomolecular conjugation.

General description

DSPE-PEG(2000) Maleimide is a functionalized PEG Lipid conjugate.

Packaging

5 mL Clear Glass Sealed Ampule (880126C-100mg)
5 mL Clear Glass Sealed Ampule (880126C-25mg)
5 mL Clear Glass Sealed Ampule (880126C-50mg)

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品
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MPL nano-liposomal vaccine containing P5 HER2/neu-derived peptide pulsed PADRE as an effective vaccine in a mice TUBO model of breast cancer
Zamani P, et al.
J. Controlled Release, 303, 223-236 (2019)
Catalysis of imido-group hydrolysis in a maleimide conjugate
Kalia J and Raines RT
Bioorganic & Medicinal Chemistry Letters, 17, 6286?6289-6286?6289 (2007)
In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: a potential novel treatment for obstetric complications
Hua S and Vaughan B
International journal of nanomedicine, 14, 2191-2191 (2019)
Yen Ling Yeow et al.
EMBO molecular medicine, 11(12), e10923-e10923 (2019-11-12)
High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the immune-modulating cytokine
Liposomes targeted to MHC-restricted antigen improve drug delivery and antimelanoma response
Saeed M, et al.
International journal of nanomedicine, 14, 2069-2069 (2019)
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