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880123X

Avanti

DSPE-PEG(5000) Folate

Avanti Polar Lipids 880123X

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Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt):methanol (9:1)
CAS Number:
1236288-25-7
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (880123X-500ug)

manufacturer/tradename

Avanti Polar Lipids 880123X

concentration

0.5 mg/mL (880123X-500ug)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]

General description

DSPE-PEG(5000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) is incorporated into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for various cancers and myeloid leukemias. Folate targeted drug delivery is potentially used for the treatment and imaging of several cancers and inflammatory diseases. Folate conjugates are small molecules having high binding affinity for folate receptors (FR) on cell surface. Therefore, they have an ability to deliver a variety of molecular complexes to pathologic cells without affecting normal tissues.

Application

DSPE-PEG(5000) Folate may be used:
  • in preparation of folate functionalized nanoparticles (NPs)
  • in synthesis of BTPEPBI-containing nanoparticles
  • in preparation of paclitaxel loaded folate modified lipid-shell and polymer-core nanoparticles (FLPNPs)

Packaging

5 mL Clear Glass Sealed Ampule (880123X-500ug)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Folate-modified lipid--polymer hybrid nanoparticles for targeted paclitaxel delivery
Zhang L, et al.
International journal of nanomedicine, 10, 2101-2101 (2015)
Linhua Zhang et al.
International journal of nanomedicine, 10, 2101-2114 (2015-04-07)
The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a
Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging
Zhao Q, et al.
Journal of Materials Chemistry, 22(30), 15128-15135 (2012)
Lipid-PEG-Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two-Photon Fluorescence Imaging
Geng J, et al.
Small, 8(23), 3655-3663 (2012)
Junlong Geng et al.
Small (Weinheim an der Bergstrasse, Germany), 8(23), 3655-3663 (2012-08-16)
Folate functionalized nanoparticles (NPs) that contain fluorogens with aggregation-induced emission (AIE) characteristics are fabricated to show bright far-red/near-infrared fluorescence, a large two-photon absorption cross section and low cytotoxicity, which are internalized into MCF-7 cancer cells mainly through caveolae-mediated endocytosis. One-photon
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