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Safety Information

878118C

Avanti

C16-02:0 DG

Avanti Research™ - A Croda Brand 878118C

Synonym(s):

1-O-hexadecyl-2-acetyl-sn-glycerol (HAG)

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About This Item

Empirical Formula (Hill Notation):
C21H42O4
CAS Number:
77133-35-8
Molecular Weight:
358.56
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 5 mL (878118C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 878118C

concentration

1 mg/mL (878118C-5mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC

General description

C16-02:0 DG, also known as 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is an alkylacylglycerol containing primary alcohol group at the C3 position.

Application

C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) may be used to inhibit the formation of 1-O-acyl-NAS.

Biochem/physiol Actions

C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist. It exhibits growth inhibitory activity against human promyelocytic leukemia cell line HL-60. HAG acts as a precursor in the biosynthesis of platelet-activating factor via remodeling and retroconversion de novo pathway.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (878118C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

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M J McNamara et al.
Biochemical and biophysical research communications, 122(2), 824-830 (1984-07-31)
The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells
Akira Abe et al.
Journal of lipid research, 48(10), 2255-2263 (2007-07-14)
A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. LPLA2 transfers sn-1 or sn-2 acyl groups of phospholipids to the C1 hydroxyl of the short-chain ceramide N-acetylsphingosine (NAS) under acidic conditions. The
Jin Tao et al.
Cellular signalling, 21(9), 1436-1443 (2009-05-15)
Corticotropin-releasing factor (CRF) receptors have been demonstrated to be widely expressed in the central nervous system and in many peripheral tissues of mammalians. However, it is still unknown whether CRF receptors will function in cerebellar Purkinje neurons. In the present
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in

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