870128P
Avanti
16:0 DBCO PE
Avanti Polar Lipids 870128P, powder
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Synonym(s):
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl
Empirical Formula (Hill Notation):
C56H90N3O10P
Recommended Products
form
powder
packaging
pkg of 1 × 25 mg (870128P-25mg)
manufacturer/tradename
Avanti Polar Lipids 870128P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCCNC(CCC(N1CC(C=CC=C2)=C2C#CC3=C1C=CC=C3)=O)=O)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[NH4+]
General description
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl (16:0 DBCO PE) is a head group modified lipid containing dibenzocyclooctyne (DBCO). It is a widely used reagent in click chemistry.
Application
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl (16:0 DBCO PE or DPPE-DBCO) has been used in preparation of DBCO-presenting lipid bilayers. It has also been used in preparation of clickable cubosomes for antibody-free drug targeting and imaging applications.
Packaging
5 mL Amber Glass Screw Cap Vial (870128P-25mg)
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
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Simon Finn Mayer et al.
Biochimica et biophysica acta. Biomembranes, 1861(10), 183023-183023 (2019-07-22)
Pore-forming antimicrobial peptides (AMPs) are attracting interest as cytolytic antibiotics and drug delivery agents with potential use for targeting cancer cells or multidrug-resistant pathogens. Ceratotoxin A (CtxA) is an insect-derived cytolytic AMP with 36 amino acids that is thought to
Nicolas Alcaraz et al.
Bioconjugate chemistry, 29(1), 149-157 (2017-11-29)
The combination of copper-free click chemistry with metabolic labeling offers new opportunities in drug delivery. The objective of this study was to determine whether cubosomes functionalized with azide or dibenzocyclooctyne (DBCO) groups are able to undergo copper-free click chemistry with
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