860645P
Avanti
C8 Ceramide (d17:1/8:0)
Avanti Polar Lipids 860645P, powder
Sign Into View Organizational & Contract Pricing
All Photos(2)
Synonym(s):
N-octanoyl-D-erythro-sphingosine (C17 base)
Empirical Formula (Hill Notation):
C25H49NO3
Recommended Products
form
powder
packaging
pkg of 1 × 10 mg (860645P-10mg)
manufacturer/tradename
Avanti Polar Lipids 860645P
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC
General description
C8-ceramide or N-octanoyl-D-erythro-sphingosine (C17 base) is a synthetic cell-permeable sphingolipid. It is a combination of C17 analog of sphingosine and octanoic acid. Ceramides are the major lipid component in the outermost layer of the skin, the stratum corneum. C8 Ceramide plays a vital role in inducing apoptotic cell death.
Application
C8 Ceramide (d17:1/8:0) has been used to induce myriocin-treated malignant melanoma cells to increase endogenous ceramide levels.
Packaging
5 mL Amber Glass Screw Cap Vial (860645P-10mg)
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Y-S Lee et al.
Cell proliferation, 44(4), 320-329 (2011-06-08)
Melanoma is the most aggressive form of skin cancer, and it resists chemotherapy. Candidate drugs for effective anti-cancer treatment have been sought from natural resources. Here, we have investigated anti-proliferative activity of myriocin, serine palmitoyltransferase inhibitor, in the de novo
J P Witty et al.
Endocrinology, 137(12), 5269-5277 (1996-12-01)
Recent studies have demonstrated that ovarian follicle atresia occurs extensively before follicle selection into the avian preovulatory hierarchy, and that this process is mediated via granulosa cell apoptosis. Subsequent to follicle selection, granulosa cells are inherently resistant to apoptosis, and
Luisa Coderch et al.
American journal of clinical dermatology, 4(2), 107-129 (2003-01-30)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service