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Merck
CN

860562C

Avanti

18:1-12:0 Biotin PE

Avanti Research™ - A Croda Brand

Synonym(s):

1-oleoyl-2-(12-biotinyl(aminododecanoyl))-sn-glycero-3-phosphoethanolamine

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About This Item

Empirical Formula (Hill Notation):
C45H83N4O10PS
CAS Number:
799812-67-2
Molecular Weight:
903.20
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

18:1-12:0 Biotin PE, Avanti Research™ - A Croda Brand 860562C

form

liquid

assay

>99% (TLC)

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCCCCCCNC(CCCC[C@]1([H])SC[C@@]2([H])[C@]1([H])NC(N2)=O)=O)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

InChI

1S/C45H83N4O10PS/c1-2-3-4-5-6-7-8-9-10-11-12-14-17-20-23-30-42(51)56-35-38(36-58-60(54,55)57-34-32-46)59-43(52)31-24-21-18-15-13-16-19-22-27-33-47-41(50)29-26-25-28-40-44-39(37-61-40)48-45(53)49-44/h9-10,38-40,44H,2-8,11-37,46H2,1H3,(H,47,50)(H,54,55)(H2,48,49,53)/b10-9-/t38-,39+,40+,44+/m1/s1

InChI key

HACDNRDNASOHSM-IBTAXAMTSA-N

packaging

pkg of 1 × 1 mL (860562C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860562C

concentration

1 mg/mL (860562C-1mg)

shipped in

dry ice

storage temp.

−20°C

Application

18:1-12:0 Biotin PE has been used:
  • as a ligand in phosphoethanolamine binding assay
  • in the generation of vesicle reconstituted with syntaxin-1A and Synaptosomal nerve-associated protein 25 (SNAP-25) vesicles
  • in the preparation of biotinylated liposomes

Biochem/physiol Actions

1-oleoyl-2-(12-biotinyl(aminododecanoyl))-sn-glycero-3-phosphoethanolamine, biotin PE is majorly used in the generation of lipid vesicle in supported lipid bilayer. It is also used in generation of phospholipid vesicle.

Packaging

5 mL Clear Glass Sealed Ampule (860562C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

危险化学品
易制毒化学品（2类）
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Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18
Lai Y, et al.
Neuron, 95(3), 591-607 (2017)
Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity
Meems H, et al.
Blood, 114(18), 3938-3946 (2009)
TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis
Lin J, et al.
BMC Immunology, 17(1), 5-5 (2016)
Nolan C Worstell et al.
PloS one, 11(4), e0153265-e0153265 (2016-04-14)
Protein-glycan recognition is often mediated by multivalent binding. These multivalent bindings can be further complicated by cooperative interactions between glycans and individual glycan binding subunits. Here we have demonstrated a nanocube-based lipid bilayer array capable of quantitatively elucidating binding dissociation
Matthew Brecher et al.
Journal of virology, 86(1), 364-372 (2011-10-28)
Cellular entry of Ebola virus (EBOV), a deadly hemorrhagic fever virus, is mediated by the viral glycoprotein (GP). The receptor-binding subunit of GP must be cleaved (by endosomal cathepsins) in order for entry and infection to proceed. Cleavage appears to
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