Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

860550P

Avanti

Biotin Sphingosine

Avanti Research™ - A Croda Brand 860550P, powder

Synonym(s):

omega-biotinyl D-erythro-sphingosine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C28H52N4O4S
CAS Number:
752987-57-8
Molecular Weight:
540.80
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860550P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860550P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@]1(CCCCC(NCCCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@](N)([H])CO)=O)SC[C@@]2([H])[C@]1([H])NC(N2)=O

InChI

1S/C28H52N4O4S/c29-22(20-33)24(34)16-12-10-8-6-4-2-1-3-5-7-9-11-15-19-30-26(35)18-14-13-17-25-27-23(21-37-25)31-28(36)32-27/h12,16,22-25,27,33-34H,1-11,13-15,17-21,29H2,(H,30,35)(H2,31,32,36)/b16-12+/t22-,23-,24+,25-,27-/m0/s1

InChI key

NYQVYZZGZCNEMF-RPRIXWAOSA-N

General description

Biotin Sphingosine is a derivative of sphingosine. It contains a biotin moiety linked to the ω-terminal of its fatty-acid chain.

Application

Biotin Sphingosine has been used as a substrate in sphingosine kinases (SphK) assay. It has also been used to label wt- ceramide synthase 1 (CerS1) expressed in UM-SCC-22A cells, to study the interaction between CerS1-generated C18-ceramide and light chain 3 β (LC3B).

Biochem/physiol Actions

Biotin Sphingosineplays a vital role in identifying sphingosine interaction with acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A).

Packaging

5 mL Amber Glass Screw Cap Vial (860550P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Bioactive Sphingolipids in Cancer Biology and Therapy (2015)
An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes
Roberts J, et al.
Analytical biochemistry, 331(1), 122-129 (2004)
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Sentelle R, et al.
Nature Chemical Biology, 8(10), 831-831 (2012)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service