860457P
Avanti
N-C24:1-deoxysphingosine
N-nervonoyl-1-deoxysphingosine (m18:1/24:1), powder
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Synonym(s):
N-(15Z-tetracosenoyl)-1-deoxysphing-4-enine (m18:1/24:1); N-C24:1-1-deoxyCer; 110996
Empirical Formula (Hill Notation):
C42H81NO2
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860457P-1mg)
manufacturer/tradename
Avanti Polar Lipids 860457P
lipid type
sphingolipids
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
General description
The sphingoid bases sphingosine is acylated with fatty acids with varying acyl-chain resulting in the synthesis of 1-deoxydihydroceramides (1-deoxyDHCers). These deoxyDHCers are further converted to 1-deoxyceramides (1-deoxysphingosine) and 1-(deoxymethyl)ceramides. They are produced by mammals.
Biochem/physiol Actions
The 1-deoxydihydroceramides are hydrophobic and interact with monolayers and giant unilamellar vesicles. They modulate cell membrane and may affect their biological functionality.
Packaging
5 mL Amber Glass Screw Cap Vial (860457P-1mg)
WGK
WGK 3
Certificates of Analysis (COA)
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Biophysical properties of novel 1-deoxy-(dihydro) ceramides occurring in mammalian cells
Jimenez-Rojo N, et al.
Biophysical Journal, 107(12), 2850-2859 (2014)
Sarah T Pruett et al.
Journal of lipid research, 49(8), 1621-1639 (2008-05-24)
"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now
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