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860103P

Avanti

18:1 Phosphatidylpropanol

Name: 18:1 Phosphatidylpropanol
Brand: AVANTI

1,2-dioleoyl-sn-glycero-3-phosphopropanol (sodium salt), powder

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Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphopropanol (sodium salt)

Empirical Formula (Hill Notation):

C₄₂H₇₈O₈PNa

CAS Number:

384835-46-5

Molecular Weight:

765.03

UNSPSC Code:

12352211

NACRES:

NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (860103P-25mg)

manufacturer/tradename

Avanti Polar Lipids 860103P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

InChI

1S/C42H79O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-41(43)47-38-40(39-49-51(45,46)48-37-6-3)50-42(44)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h19-22,40H,4-18,23-39H2,1-3H3,(H,45,46);/q;+1/p-1/b21-19-,22-20-;/t40-;/m1./s1

InChI key

ZGATVCGNENIEOO-MYJLHYLNSA-M

Application

18:1 Phosphatidylpropanol or 1,2-dioleoyl-sn-glycero-3-phosphopropanol (sodium salt) may be used as an internal standard:

in ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) to evaluate its matrix effect in blood samples for the validation of phosphatidylethanol (PEth)
for the quantification of PEth using liquid chromatography tandem mass spectrometry (LC-MS/MS) in human blood
for the quantification of PEth using liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) in human blood

Packaging

5 mL Clear Glass Sealed Ampule (860103P-25mg)

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Method development for routine liquid chromatography-mass spectrometry measurement of the alcohol biomarker phosphatidylethanol (PEth) in blood.

Yufang Zheng et al.

Clinica chimica acta; international journal of clinical chemistry, 412(15-16), 1428-1435 (2011-05-03)

Phosphatidylethanol (PEth) is a group of phospholipids formed from ethanol and phosphatidylcholine by action of phospholipase D. Measurement of PEth in whole blood samples is employed as an alcohol biomarker. This work aimed to further develop an LC-MS method for

Simultaneous determination of ethanol's four types of non-oxidative metabolites in human whole blood by liquid chromatography tandem mass spectrometry.

Xinyu Zhang et al.

Analytica chimica acta, 963, 68-75 (2017-03-25)

The importance of ethanol non-oxidative metabolites as the specific biomarkers of alcohol consumption in clinical and forensic settings is increasingly acknowledged. Simultaneous determination of these metabolites can provide a wealth of information like drinking habit and history, but it was

Quantification of phosphatidylethanol 16:0/18:1, 18:1/18:1, and 16:0/16:0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers.

Natalie Kummer et al.

Analytical and bioanalytical chemistry, 408(3), 825-838 (2015-11-26)

Phosphatidylethanol species (PEths) are promising biomarkers of alcohol consumption. Here, we report on the set-up, validation, and application of a novel UHPLC-ESI-MS/MS method for the quantification of PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 in whole blood (30 μL) and

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