All Photos(1)
Synonym(s):
(2R,3S)-3-hydroxy-2-(3-(6-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
Empirical Formula (Hill Notation):
C22H27N5O3
Recommended Products
Assay
99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857382P-1MG)
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
N=C(N)N1CC[C@H](O)[C@@H]1C2=NC(C3=CC4=CC=C(OCCCCC)C=C4C=C3)=NO2
General description
SLC5111312 is a selective inhibitor of mouse sphingosine kinase 2 (SphK2). It also inhibits rat and human sphingosine kinase type 1 and type 2 (SphK1/2). It is made up of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.
Biochem/physiol Actions
SLC5111312 increases the blood sphingosine 1-phosphate (S1P) levels in mice due to the inhibition of sphingosine kinase type 2 (SphK2).
Packaging
5ML Amber Glass Screw Cap Vial (857382P-1MG)
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors
Kharel Y, et al.
PLoS ONE, 13(4), 23-31 (2018)
Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels
Kharel Y, et al.
Journal of Pharmacology and Experimental Therapeutics, 355(1), 23-31 (2015)
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