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Safety Information

855775C

Avanti

18:0 Lyso PC

1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine, chloroform

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Synonym(s):
1-octadecanoyl-sn-glycero-3-phosphocholine; PC(18:0/0:0)
Empirical Formula (Hill Notation):
C26H54NO7P
CAS Number:
19420-57-6
Molecular Weight:
523.68
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (855775C-25mg)
pkg of 1 × 20 mL (855775C-500mg)

manufacturer/tradename

Avanti Polar Lipids 855775C

concentration

10 mg/mL (855775C-25mg)
25 mg/mL (855775C-500mg)

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C26H54NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h25,28H,5-24H2,1-4H3

InChI key

IHNKQIMGVNPMTC-UHFFFAOYSA-N

Application

18:0 Lyso PC has been used in gametocytogenesis assay.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (855775C-500mg)
5 mL Clear Glass Sealed Ampule (855775C-25mg)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Regulatory Information

危险化学品
易制毒化学品（2类）

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum
Brancucci NMB, et al.
Cell, 171(7), 1532-1544 (2017)
Anthony J Valente et al.
Free radical biology & medicine, 70, 117-128 (2014-02-25)
Oxidized low-density lipoprotein (oxLDL) induces endothelial cell death through the activation of NF-κB and AP-1 pathways. TRAF3IP2 is a redox-sensitive cytoplasmic adapter protein and an upstream regulator of IKK/NF-κB and JNK/AP-1. Here we show that oxLDL-induced death in human primary
Otto K Kari et al.
Nanoscale, 12(3), 1728-1741 (2020-01-03)
Methodological constraints have limited our ability to study protein corona formation, slowing nanomedicine development and their successful translation into the clinic. We determined hard and soft corona structural properties along with the corresponding proteomic compositions on liposomes in a label-free
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells
Dumindika A Siriwardane et al.
International journal of pharmaceutics, 578, 119077-119077 (2020-01-29)
Identification and quantification of excipient related degradation products in the liposomal formulation is important, as they may impact the safety and efficacy of the drug. Phospholipids are one of the major excipients in liposome drugs composing the lipid bilayer, and
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Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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