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850755C

Avanti

18:2 PE

1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine, chloroform

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Synonym(s):
1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine; PE(18:2(9Z,12Z)/18:2(9Z,12Z))
Empirical Formula (Hill Notation):
C41H74NO8P
CAS Number:
20707-71-5
Molecular Weight:
740.00
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850755C-25mg)
pkg of 2 × 4 mL (850755C-200mg)

manufacturer/tradename

Avanti Polar Lipids 850755C

concentration

10 mg/mL (850755C-25mg)
25 mg/mL (850755C-200mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O

General description

Phosphatidylethanolamine (PE) is the second most plenteous glycerophospholipid in eukaryotic cells. It is a non-bilayer forming phospholipid, which is found majorly in the mitochondria. It consists of a small polar head group with fatty acid chains.

Application

18:2 PE has been used for the preparation of liposomes.

Biochem/physiol Actions

Phosphatidylethanolamine (PE) functions as to provide rigidity to the cell membranes via hexagonal phase structures which promote tight packing of the membrane bilayer formed by phosphatidylcholine. It is also involved in the conversion of prions from the non-toxic to toxic conformation. PE also initiates the autophagosome formation by attaching covalently to the autophagy Atg8 protein.

Packaging

5 mL Clear Glass Sealed Ampule (850755C-200mg)
5 mL Clear Glass Sealed Ampule (850755C-25mg)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Liver,Kidney, Respiratory system

WGK

WGK 3

Regulatory Information

易制毒化学品（2类）
危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phosphatidylethanolamine metabolism in health and disease
International Review of Cell and Molecular Biology, 321, 29-88 (2016)
Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
Manni M M, et al.
eLife, 7, e34394-e34394 (2018)
Ethanolamine and Phosphatidylethanolamine Partners in Health and Disease
Patel D and Witt SN
Oxidative Medicine and Cellular Longevity, 2017, 29-88 (2017)

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