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850545P

Avanti

LDAO

Avanti Polar Lipids

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Synonym(s):
N,N-dimethyldodecylamine N-oxide
Empirical Formula (Hill Notation):
C14H31NO
CAS Number:
1643-20-5
Molecular Weight:
229.40
UNSPSC Code:
12161902
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

mol wt

229.40 g/mol

packaging

pkg of 1 × 1 g (850545P-1g)
pkg of 1 × 5 g (850545P-5g)

manufacturer/tradename

Avanti Polar Lipids

technique(s)

electrophoresis: suitable

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCC[N+](C)([O-])C

InChI

1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3

InChI key

SYELZBGXAIXKHU-UHFFFAOYSA-N

General description

An optimized reverse micelle surfactant system has been developed for solution nuclear magnetic resonance studies of encapsulated proteins and nucleic acids dissolved in low viscosity fluids. Comprising the nonionic 1-decanoyl-rac-glycerol and the zwitterionic lauryldimethylamine-N-oxide (10MAG/LDAO), this mixture is shown to efficiently encapsulate a diverse set of proteins and nucleic acids. Chemical shift analyses of these systems show that high structural fidelity is achieved upon encapsulation.
LDAO (N,N-Dimethyldodecylamine N-oxide) is a zwitterionic detergent.

Application

LDAO is suitable to use in crystallization of membrane proteins. It is also suitable to enhance the detection of high molecular weight proteins.

Biochem/physiol Actions

LDAO can be used to disrupt phospholipid bilayer of cells.

Packaging

20 mL Clear Glass Screw Cap Vial (850545P-1g)
60 mL Amber Wide Mouth Glass Bottle with Screw Cap (850545P-5g)

Signal Word

Danger

Hazard Statements

H302,H315,H318,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Detergents for the stabilization and crystallization of membrane proteins
Prive GG
Methods, 41(4), 388-397 (2007)
MALDI mass spectrometry analysis of high molecular weight proteins from whole bacterial cells: pretreatment of samples with surfactants
Meetani MA and Voorhees KJ
Journal of the American Society For Mass Spectrometry, 16(9), 1422-1426 (2005)
Igor Dodevski et al.
Journal of the American Chemical Society, 136(9), 3465-3474 (2014-02-06)
An optimized reverse micelle surfactant system has been developed for solution nuclear magnetic resonance studies of encapsulated proteins and nucleic acids dissolved in low viscosity fluids. Comprising the nonionic 1-decanoyl-rac-glycerol and the zwitterionic lauryldimethylamine-N-oxide (10MAG/LDAO), this mixture is shown to

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