850458P
Avanti
16:0-18:2 PC
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine, powder
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Synonym(s):
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; PC(16:0/18:2(9Z,12Z))
Empirical Formula (Hill Notation):
C42H80NO8P
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 2 × 100 mg (850458P-200mg)
pkg of 1 × 25 mg (850458P-25mg)
manufacturer/tradename
Avanti Polar Lipids 850458P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O
General description
16:0-18:2 PC or 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine is a glycerophospholipid, with substitution of palmitic acid and linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, respectively.
Application
16:0-18:2 PC or 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine:
- has been used in liposomes for standard cell-free translation
- has been used in the extraction of serum lipids and in peroxisome proliferator-activated receptor-δ (PPAR-δ) assay
- might be used to study the effects of phosphatidylcholines (PCs) on lubrication of damaged mesothelium
Packaging
5 mL Clear Glass Sealed Ampule (850458P-200mg)
5 mL Clear Glass Sealed Ampule (850458P-25mg)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Giulia Coliva et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-25)
Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty acyl chain composition, presence
Lindsay Kosack et al.
Scientific reports, 7(1), 11289-11289 (2017-09-14)
Lipid metabolism is increasingly being appreciated to affect immunoregulation, inflammation and pathology. In this study we found that mice infected with lymphocytic choriomeningitis virus (LCMV) exhibit global perturbations of circulating serum lipids. Mice lacking the lipid-sensing surface receptor triggering receptor
Francesca Bodega et al.
Respiratory physiology & neurobiology, 203, 116-120 (2014-08-17)
Effect of time and phosphatidylcholines (PCs) on lubrication of damaged mesothelium has been investigated. Marked increase in coefficient of kinetic friction (μ) of pleural specimens after mesothelial blotting and rewetting decreased by 23.4±3.5%, 41.8±3.8%, and 40.5±2.7% after 30min, 1h, and
John K Eaton et al.
Nature chemical biology, 16(5), 497-506 (2020-04-02)
We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy resistance by multiple types of treatment results in a stable cell state marked by high levels of polyunsaturated
Eikan Mishima et al.
Journal of the American Society of Nephrology : JASN, 31(2), 280-296 (2019-11-27)
Ferroptosis, nonapoptotic cell death mediated by free radical reactions and driven by the oxidative degradation of lipids, is a therapeutic target because of its role in organ damage, including AKI. Ferroptosis-causing radicals that are targeted by ferroptosis suppressors have not
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