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850445P

Avanti

14:0-16:0 PC

1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine, powder

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Synonym(s):
1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine; MPPC; PC(14:0/16:0)
Empirical Formula (Hill Notation):
C38H76NO8P
CAS Number:
69525-80-0
Molecular Weight:
705.99
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (850445P-25mg)
pkg of 1 × 500 mg (850445P-500mg)

manufacturer/tradename

Avanti Polar Lipids 850445P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)=O

InChI

1S/C38H76NO8P/c1-6-8-10-12-14-16-18-19-21-23-25-27-29-31-38(41)47-36(35-46-48(42,43)45-33-32-39(3,4)5)34-44-37(40)30-28-26-24-22-20-17-15-13-11-9-7-2/h36H,6-35H2,1-5H3/t36-/m1/s1

InChI key

RFVFQQWKPSOBED-PSXMRANNSA-N

General description

Phosphatidylcholines (PCs) are phospholipids, that are abundantly present in the tissues of animal. PCs consist of saturated and unsaturated fatty acids in the sn-1 and sn-2 position respectively.

Application

14:0-16:0 PC (1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine) may be used:
  • in the bilayer membrane to study its miscibility with d-erythro-N-palmitoyl-sphingomyelin (16:0-SM) using differential scanning calorimetry (DSC)
  • as a negative control in stimulation studies to study its effect on insect immune deficiency (IMD) pathway
  • in generating Wnt3a liposomes

Biochem/physiol Actions

Phosphatidylcholines (PCs) participates in reducing the level of blood lipid and cholesterol.

Packaging

20 mL Clear Glass Screw Cap Vial (850445P-500mg)
5 mL Amber Glass Screw Cap Vial (850445P-25mg)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lipids II: Phospholipids, Glycosphingolipids, and Cholesterol
Essentials of Medical Biochemistry, 299-320 (2015)
Bohdana Térová et al.
Biochimica et biophysica acta, 1667(2), 182-189 (2004-12-08)
In this study we have used differential scanning calorimetry (DSC) to study the miscibility of different saturated phosphatidylcholines (PCs) with D-erythro-N-palmitoyl-sphingomyelin (16:0-SM). Information about the miscibility was obtained by observing the thermotropic phase behavior of binary mixtures of saturated PCs
Li-Juan Zhao et al.
Journal of ethnopharmacology, 260, 112943-112943 (2020-05-19)
Arenobufagin (ArBu) is an important anti-tumor ingredient of Chan'su which has long been used as traditional Chinese medicine in clinic for tumor therapy in China. The purpose of our study is to investigate the lipid homeostasis regulation effects of ArBu
Nathan T Morrell et al.
PloS one, 3(8), e2930-e2930 (2008-08-14)
Wnt signals exercise strong cell-biological and regenerative effects of considerable therapeutic value. There are, however, no specific Wnt agonists and no method for in vivo delivery of purified Wnt proteins. Wnts contain lipid adducts that are required for activity and
Dana K Shaw et al.
Nature communications, 8, 14401-14401 (2017-02-15)
The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids
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