Skip to Content
Merck
CN

850395C

Avanti

18:3 (Cis) PC

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dilinolenoyl-sn-glycero-3-phosphocholine

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C44H76NO8P
CAS Number:
2701-19-1
Molecular Weight:
778.05
MDL number:
MFCD00144544
NACRES:
NA.25
UNSPSC Code:
51191904

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

18:3 (Cis) PC, Avanti Research™ - A Croda Brand 850395C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850395C-25mg), pkg of 2 × 4 mL (850395C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850395C

concentration

10 mg/mL (850395C-25mg), 25 mg/mL (850395C-200mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

General description

18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine is an unsaturated glycerophospholipid, with substitution of two chains of linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, along with choline as a headgroup.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine:
  • might be used in aqueous lipid-trehalose formulations to assess the long-term storage stability of lyophilized liposomes
  • might be used in phospholipid monolayer to study the instability of unsaturated phospholipids at specified conditions
  • has been used in aqueous sugar formulations or liposome formulations to characterize its degradation during lyophilization

Packaging

5 mL Clear Glass Sealed Ampule (850395C-200mg)
5 mL Clear Glass Sealed Ampule (850395C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

危险化学品
易制毒化学品（2类）
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

N M Payton et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 85(2), 306-313 (2013-04-10)
As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g., lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during lyophilization and/or during prolonged storage. The goal of the current
Jonathan F D Liljeblad et al.
Biophysical journal, 98(10), L50-L52 (2010-05-21)
The surface specific technique vibrational sum frequency spectroscopy has been applied to in situ studies of the degradation of Langmuir monolayers of 1,2-diacyl-phosphocholines with various degrees of unsaturation in the aliphatic chains. To monitor the degradation of the phospholipids, the
Nicole M Payton et al.
Journal of pharmaceutical sciences, 103(12), 3869-3878 (2014-10-14)
Because aqueous liposomal formulations containing multiply unsaturated lipids are susceptible to chemical degradation, these formulations are often lyophilized. Despite their limited chemical stability, interest in the use of multiply unsaturated lipids to promote intracellular delivery has increased considerably in recent

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service