850373P
Avanti
24:0 PC
1,2-dilignoceroyl-sn-glycero-3-phosphocholine, powder
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Synonym(s):
1,2-ditetracosanoyl-sn-glycero-3-phosphocholine; PC(24:0/24:0) ; 110929
Empirical Formula (Hill Notation):
C56H112NO8P
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (850373P-200mg)
pkg of 1 × 25 mg (850373P-25mg)
manufacturer/tradename
Avanti Polar Lipids 850373P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCC[N+](C)(C)C)=O)(OC(CCCCCCCCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCCCCCCCC)=O
General description
24:0 PC (1,2-dilignoceroyl-sn-glycero-3-phosphocholine) is a long-chain diacyl phospholipid. It consists of C24 saturated hydrocarbon chains.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
24:0 PC (1,2-dilignoceroyl-sn-glycero-3-phosphocholine) may be used:
- in both short-chain micelles and longer-chain oriented multilayers and in Langmuir monolayers for structural studies of the human immunodeficiency virus 1 (HIV-1) accessory protein
- to compare cohesion/to study the effects of lipid cohesion on the thermally induced revaporization and dissolution of microbubble condensed droplets (MCDs)
- to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP) and to study the effects of the its carbon chain length on α-secretase activity
Biochem/physiol Actions
Phosphatidylcholines (PCs) serve as a major source for eicosanoids.
Packaging
5 mL Amber Glass Screw Cap Vial (850373P-200mg)
5 mL Amber Glass Screw Cap Vial (850373P-25mg)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Paul A Mountford et al.
Langmuir : the ACS journal of surfaces and colloids, 31(16), 4627-4634 (2015-04-09)
This study explored the thermal conditions necessary for the vaporization of superheated perfluorocarbon nanodrops. Droplets C3F8 and C4F10 coated with a homologous series of saturated diacylphosphatidylcholines were formed by condensation of 4 μm diameter microbubbles. These drops were stable at
S Zheng et al.
Biophysical journal, 80(4), 1837-1850 (2001-03-22)
Vpu is an 81 amino acid integral membrane protein encoded by the HIV-1 genome with a N-terminal hydrophobic domain and a C-terminal hydrophilic domain. It enhances the release of virus from the infected cell and triggers degradation of the virus
Keishi Kanno et al.
Biochimica et biophysica acta, 1771(6), 654-662 (2007-05-15)
Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. PC-TP is a member of the steroidogenic acute regulatory protein-related transfer (START) domain superfamily. Although its biochemical properties and structure are
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
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