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850355P

Avanti

16:0 PC (DPPC)

Name: 16:0 PC (DPPC)
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine; DPPC; PC(16:0/16:0)

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About This Item

Empirical Formula (Hill Notation):

C₄₀H₈₀NO₈P

CAS Number:

63-89-8

Molecular Weight:

734.04

UNSPSC Code:

51191904

NACRES:

NA.25

description

1,2-dipalmitoyl-sn-glycero-3-phosphocholine

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850355P-1g)
pkg of 1 × 200 mg (850355P-200mg)
pkg of 1 × 25 mg (850355P-25mg)
pkg of 1 × 500 mg (850355P-500mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3

InChI key

KILNVBDSWZSGLL-UHFFFAOYSA-N

General description

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) is synthesized from unsaturated phosphatidylcholine (PC) by direct de novo synthesis via α1,2-dipalmitoyl diacylglycerol intermediate. The enzyme cholinephosphotransferase catalyzes the conversion of 1,2-dipalmitoyl diacylglycerol to DPPC. Synthesis of DPPC also occurs via remodeling pathway involving deacylation of unsaturated PC.

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

16:0 PC (DPPC) has been used in the generation of thymoquinone (TQ) liposomes, gold nanorods and calcium chloride encapsulated liposomes and bilayers for biophysical studies.

Biochem/physiol Actions

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) is a surfactant and reduces surface tension. It is used in combination with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) for lipid bilayer generation. DPPC alone and in combination with other phospholipid is effective in drug encapsulation and delivery.

Packaging

20 mL Clear Glass Screw Cap Vial (850355P-1g)

20 mL Clear Glass Screw Cap Vial (850355P-500mg)

5 mL Amber Glass Screw Cap Vial (850355P-200mg)

5 mL Amber Glass Screw Cap Vial (850355P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.

Description

Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells

Chen X, et al.

Proceedings of the National Academy of Sciences of the USA, 103(31), 11724-11729 (2006)

Phenotypic basis for matrix stiffness-dependent chemoresistance of breast cancer cells to doxorubicin

Joyce MH, et al.

Frontiers in Oncology, 8, 203-208 (2018)

Structural Modifications of DPPC Bilayers upon Inclusion of an Antibacterial Cationic Bolaamphiphile.

M Mamusa et al.

Langmuir : the ACS journal of surfaces and colloids, 34(30), 8952-8961 (2018-07-07)

The emergence of antibiotic-resistant bacterial strains has fostered fundamental research to develop alternative antimicrobial strategies. Among the several systems proposed so far, the association complexes (nanoplexes) formed by transcription factor decoys (TFDs), i.e., short oligonucleotides targeting a crucial bacterial transcription

Calcium and Zinc Differentially Affect the Structure of Lipid Membranes.

Norbert Kučerka et al.

Langmuir : the ACS journal of surfaces and colloids, 33(12), 3134-3141 (2017-03-10)

Interactions of calcium (Ca2+) and zinc (Zn2+) cations with biomimetic membranes made of dipalmitoylphosphatidylcholine (DPPC) were studied by small angle neutron diffraction (SAND). Experiments show that the structure of these lipid bilayers is differentially affected by the two divalent cations.

Driving force for crystallization of anionic lipid membranes revealed by atomistic simulations.

Bao Fu Qiao et al.

The journal of physical chemistry. B, 117(17), 5073-5080 (2013-04-10)

Crystalline vesicles are promising nanomaterials due to their mechanical stability in various environments. To control their fabrication, it is essential to understand the effects of different experimental conditions on crystallization. Here we perform atomistic molecular dynamics simulations of anionic lipid

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Documents

16:0 PC (DPPC)

Avanti Research™ - A Croda Brand

About This Item

Properties

description

Assay

form

packaging

manufacturer/tradename

lipid type

shipped in

storage temp.

SMILES string

InChI

InChI key

Description

General description

Application

Biochem/physiol Actions

Packaging

Legal Information

Related Products

also commonly purchased with this product

Safety Information

Storage Class Code

WGK

Flash Point(F)

Flash Point(C)

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Technical Service

Avanti Research^™ - A Croda Brand