850334P
Avanti
MAPCHO®-10
Avanti Polar Lipids 850334P, powder
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All Photos(2)
Synonym(s):
n-decylphosphocholine
Empirical Formula (Hill Notation):
C15H34NO4P
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (850334P-1g)
manufacturer/tradename
Avanti Polar Lipids 850334P
shipped in
dry ice
storage temp.
−20°C
InChI
1S/C15H34NO4P/c1-5-6-7-8-9-10-11-12-14-19-21(17,18)20-15-13-16(2,3)4/h5-15H2,1-4H3
InChI key
VVVDGSCGBGBGFN-UHFFFAOYSA-N
General description
MAPCHO®-10/n-decylphosphocholine (DPC) is a short-chain lipid like, zwitterionic detergent.
N-decylphosphocholine is a structural analog of decanoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid maybe used as a detergent for membrane protein solubilization and purification.
Biochem/physiol Actions
Dodecylphosphocholine (DPC) is mainly used to isolate and purify membrane proteins and it also acts as a membrane-mimetic micellar environment for liquid-state nuclear magnetic resonance (NMR) studies of membrane proteins.
Packaging
30 mL Amber Wide Mouth Bottle with Screw Cap (850334P-1g)
Legal Information
MAPCHO is a registered trademark of Avanti Polar Lipids, Inc.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta (2012)
Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta, 1818(5), 1142-1147 (2012)
Roman Brunecky et al.
Biochemistry, 44(49), 16064-16071 (2005-12-08)
A growing number of modules including FYVE domains target key signaling proteins to membranes through specific recognition of lipid headgroups and hydrophobic insertion into bilayers. Despite the critical role of membrane insertion in the function of these modules, the structural
Reto Horst et al.
The journal of physical chemistry. B, 116(23), 6775-6780 (2012-02-18)
Aqueous solutions of the detergent Fos-10 (n-decylphosphocholine) without and with addition of the integral membrane protein (IMP) OmpX (outer membrane protein X) have been characterized using pulsed field gradient-stimulated echo (PFG-STE) NMR experiments for measurements of translational diffusion coefficients. Effective
Pasquale Palladino et al.
Journal of fluorescence, 20(1), 191-196 (2009-09-17)
We have investigated the effect of ionic strength on the aggregation behavior of n-dodecyl phosphocholine. On the basis of the classical Corrin-Harkins relation, the critical micellar concentration of this detergent decreases with a biphasic trend on lithium chloride addition. It
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