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850188P

Avanti

18:0-20:4 PI(3,4)P2

powder

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Synonym(s):
1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt)
Empirical Formula (Hill Notation):
C47H94N3O19P3
CAS Number:
2315262-41-8
Molecular Weight:
1098.18
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

99% (TLC)

form

powder

packaging

package of 1 × 100 μg (850188P-100UG)
package of 1 × 500 μg (850188P-500UG)

manufacturer/tradename

Avanti Polar Lipids

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP(O)([O-])=O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

General description

PI(3,4)P2 is a lipid secondary messenger. It is obtained from the dephosphorylation of PI(3,4,5)P3 by 5-phosphatase.

Biochem/physiol Actions

PI(3,4)P2 plays a role in protein kinase B (PKB) phosphorylation on Ser473 in mast cells. It also binds to certain effectors such as serine/threonine-specific protein kinase (AKT) and dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1). It also regulates the activity of actin mesh which is associated with endocytic structures.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850188P-100UG)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850188P-500UG)

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PTEN regulates PI (3, 4) P2 signaling downstream of class I PI3K
Malek M, et al.
Molecular Cell, 68(3), 566-580 (2017)
PI (3, 4, 5) P3 and PI (3, 4) P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI (3, 4) P2 levels determine PKB activity
Ma K, et al.
Cellular Signalling, 20(4), 684-694 (2008)

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