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850184P

Avanti

08:0 PI(3,5)P2

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,5′-bisphosphate) (ammonium salt), powder

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Synonym(s):
PIP2[3′,5′](8:0/8:0); 110664
Empirical Formula (Hill Notation):
C25H58N3O19P3
CAS Number:
852043-36-8
Molecular Weight:
797.66
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850184P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850184P-500ug))

manufacturer/tradename

Avanti Polar Lipids 850184P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]

General description

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is the least found phosphoinositides (PIs) and it accounts for approximately 0.05 to 0.1% of total cellular PI.

Biochem/physiol Actions

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) plays a key role in the embryonic development. It is very essential at postnatal stages. It is capable of activating ion channels on endosomes and lysosomes.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850184P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850184P-500ug)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Junya Hasegawa et al.
Cell structure and function, 42(1), 49-60 (2017-03-18)
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial
Bong-Kwan Han et al.
The Journal of biological chemistry, 288(28), 20633-20645 (2013-06-05)
Glucose/carbon metabolism is a fundamental cellular process in living cells. In response to varying environments, eukaryotic cells reprogram their glucose/carbon metabolism between aerobic or anaerobic glycolysis, oxidative phosphorylation, and/or gluconeogenesis. The distinct type of glucose/carbon metabolism that a cell carries
Gerald R V Hammond et al.
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

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