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850183P

Avanti

08:0 PI(3,4)P2

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt), powder

Synonym(s):

PIP2[3′,4′](8:0/8:0); 110666

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About This Item

Empirical Formula (Hill Notation):
C25H58N3O19P3
CAS Number:
852043-35-7
Molecular Weight:
797.66
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850183P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850183P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 850183P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]

General description

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Application

08:0 PI(3,4)P2 (1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt)) has been used in hydrogen deuterium exchange mass spectrometry (HDX-MS) to compare the dynamics of full-length wild-type (WT) sorting nexin 9 (SNX9)/used in lipid mixture for SNX9 tubulation assay. It may also be used in liposomes for nanoparticle tracking analysis.

Biochem/physiol Actions

Phosphatidylinositol 3,4,-biphosphate (PI(3,4)P2) serves as a lipid second messenger.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850183P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850183P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wen-Ting Lo et al.
Developmental cell, 43(4), 522-529 (2017-11-22)
Clathrin-mediated endocytosis occurs by bending and remodeling of the membrane underneath the coat. Bin-amphiphysin-rvs (BAR) domain proteins are crucial for endocytic membrane remodeling, but how their activity is spatiotemporally controlled is largely unknown. We demonstrate that the membrane remodeling activity
Leonardo Almeida-Souza et al.
Cell, 174(2), 325-337 (2018-06-12)
Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that
Gerald R V Hammond et al.
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

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