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850176P

Avanti

06:0 PI(3,4,5)P3

1,2-dihexanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder

Synonym(s):

PIP3[3′,4′,5′](6:0/6:0)

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About This Item

Empirical Formula (Hill Notation):
C21H54N4O22P4
CAS Number:
799268-62-5
Molecular Weight:
838.56
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (850176P-1MG)
pkg of 1 × 100 μg (with stopper and crimp cap (850176P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850176P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 850176P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]

General description

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Biochem/physiol Actions

Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) acts as a lipid second messenger. It is capable of triggering protein kinase B (PKB) phosphorylation. PI(3,4,5) may play a role in the modulation of synaptic activity.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850176P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850176P-500ug)
5 mL Amber Glass Screw Cap Vial (850176P-1MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rays H Y Jiang et al.
Cell host & microbe, 11(2), 99-100 (2012-02-22)
Survival of blood stage malaria parasites requires extensive host cell remodeling, which is facilitated by secretion of parasite proteins via a dedicated protein export pathway. In a recent Cell paper, Bhattacharjee et al., (2012) describe PI(3)P binding as one of the
Sulochanadevi Baskaran et al.
Molecular cell, 47(3), 339-348 (2012-06-19)
Macroautophagy is essential to cell survival during starvation and proceeds by the growth of a double-membraned phagophore, which engulfs cytosol and other substrates. The synthesis and recognition of the lipid phosphatidylinositol 3-phosphate, PI(3)P, is essential for autophagy. The key autophagic
Kewei Ma et al.
Cellular signalling, 20(4), 684-694 (2008-02-06)
The PI3K-PKB pathway is an important and widely studied pathway in cell signaling. The enzyme activity of PI3K produces D-3 phosphoinositides, including the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. PI(3,4,5)P3 has been deemed to be the most important second messenger
Thang Manh Khuong et al.
Neuron, 77(6), 1097-1108 (2013-03-26)
PI(3,4,5)P3 is a low-abundance lipid thought to play a role in the regulation of synaptic activity; however, the mechanism remains obscure. We have constructed novel split Venus-based probes and used superresolution imaging to localize PI(3,4,5)P3 at Drosophila larval neuromuscular synapses. We find
Gerald R V Hammond et al.
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

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