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850174P

Avanti

06:0 PI(3,5)P2

1,2-dihexanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,5′-bisphosphate) (ammonium salt), powder

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Synonym(s):
PIP2[3′,5′](6:0/6:0)
Empirical Formula (Hill Notation):
C21H50N3O19P3
CAS Number:
799268-61-4
Molecular Weight:
741.55
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850174P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850174P-500ug))

manufacturer/tradename

Avanti Polar Lipids 850174P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCC)=O)COC(CCCCC)=O.[NH4+].[NH4+].[NH4+]

General description

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is an inositol phospholipid, which accounts for approximately 0.05-0.1% of total cellular phosphatidylinositol (PI). In fungi and higher eukaryotes, this less abundant phosphoinositide is present in the endosomal and lysosomal membranes.

Biochem/physiol Actions

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is capable of activating ion channels on endosomes and lysosomes. It also activates mammalian target of rapamycin complex 1 (mTORC1) in yeast and in some mammalian cell types.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850174P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850174P-500ug)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sheena Claire Li et al.
Molecular biology of the cell, 25(8), 1251-1262 (2014-02-14)
Vacuolar proton-translocating ATPases (V-ATPases) are highly conserved, ATP-driven proton pumps regulated by reversible dissociation of its cytosolic, peripheral V1 domain from the integral membrane V(o) domain. Multiple stresses induce changes in V1-V(o) assembly, but the signaling mechanisms behind these changes
Junya Hasegawa et al.
Cell structure and function, 42(1), 49-60 (2017-03-18)
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial
Gerald R V Hammond et al.
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

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