850081P
Avanti
Monolyso Heart CA
Avanti Polar Lipids 850081P, powder
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All Photos(3)
Synonym(s):
monolysocardiolipin (Heart, Bovine) (sodium salt)
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (850081P-10mg)
manufacturer/tradename
Avanti Polar Lipids 850081P
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=P([O-])(OC[C@]([H])(O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O.[Na+].[Na+]
General description
Monolysocardiolipin (MLCL) is a class of phospholipid related to cardiolipin. MLCL is a triacylated phospholipid, uncommon in bacterial or eukaryotic membranes. MLCL is prepared from cardiolipin by the hydrolysis action of phospholipase A2 (PLA2).
Application
Monolyso Heart CA is suitable for use:
- as substrate for the synthesis of cardiolipin by the enzyme acyl-CoA:lysocardiolipin acyltransferase (ACLAT1)
- as substrate for the assay of mitochondrial monolysocardiolipin acyltransferase (MLCL AT) activity
- in the preparation of affinity resin MLCL-adriamycin-agarose for the purification of MLCL AT
Biochem/physiol Actions
Monolysocardiolipin (MLCL) is a substrate for the biosynthesis of cardiolipin in heart by the activity of MLCL acyltransferase. MLCL is a marker for Barth syndrome. MLCL is implicated in apoptosis.
Packaging
5 mL Clear Glass Sealed Ampule (850081P-10mg)
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart
Mutter T, et al.
The Biochemical Journal, 346(2), 403-406 (2000)
Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
Taylor WA and Hatch GM
The Journal of Biological Chemistry, 284(44), 30360-30371 (2009)
Monolysocardiolipin: improved preparation with high yield
Kim J and Hoppel CL
Journal of Lipid Research, 52(2), 389-392 (2011)
Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii
Lopalco P, et al.
Scientific Reports, 7(1), 2972-2972 (2017)
Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome
Van Werkhoven MA, et al.
Journal of Lipid Research, 47(10), 2346-2351 (2006)
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