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Merck
CN

840435P

Avanti

12:0 PG

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-didodecanoyl-sn-glycero-3-phospho-(1′racglycerol) (sodium salt); DLPG; PG(12:0/12:0)

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About This Item

Empirical Formula (Hill Notation):
C30H58O10PNa
CAS Number:
322647-27-8
Molecular Weight:
632.74
MDL number:
MFCD00135194
UNSPSC Code:
51191904
NACRES:
NA.25

Key Documents

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Product Name

12:0 PG, Avanti Research™ - A Croda Brand

SMILES string

[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC)OCC(O)CO

InChI

1S/C30H59O10P.Na/c1-3-5-7-9-11-13-15-17-19-21-29(33)37-25-28(26-39-41(35,36)38-24-27(32)23-31)40-30(34)22-20-18-16-14-12-10-8-6-4-2;/h27-28,31-32H,3-26H2,1-2H3,(H,35,36);/q;+1/p-1/t27?,28-;/m1./s1

InChI key

CIRSYGHBBDDURM-AMRYRHMLSA-M

description

1,2-dilauroyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 200 mg (840435P-200mg)
pkg of 1 × 25 mg (840435P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

12:0 PG (1,2-dilauroyl-sn-glycero-3-phospho-(1′-rac-glycerol)) has been used in monomolecular films as representative lipid component of eukaryotic membranes to study the generality of the non-steroidal anti-inflammatory drug (NSAID)-related effect. It may also be used:
  • in the preparation of liposomes for PagP folding assays
  • as a component in pyrene labeleld liposomes
  • to construct liposome/lipid vesicle

Biochem/physiol Actions

Phosphatidylglycerol (PG) is known to participate in photosynthesis.

General description

Phosphatidylglycerol (PG) is one of the most important lipid, found in Gram-positive bacteria. It has odd-numbered branched-chain fatty acids as acyl chains. This phospholipid is ubiquitously present in the membranes of several organisms. 12:0 PG (1,2-dilauroyl-sn-glycero-3-phospho-(1′-rac-glycerol)/DLPG) is an anionic phospholipid. It is an anionic analogue of the zwitterionic phospholipid, dilauroyl phosphatidylcholine (DLPC).

Packaging

5 mL Amber Glass Screw Cap Vial (840435P-200mg)
5 mL Amber Glass Screw Cap Vial (840435P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Gerardino D'Errico et al.
Biochimica et biophysica acta, 1778(12), 2710-2716 (2008-08-19)
There is mounting evidence that the lipid matrix of neuronal cell membranes plays an important role in the accumulation of beta-amyloid peptides into senile plaques, one of the hallmarks of Alzheimer's disease (AD). With the aim to clarify the molecular
FATS vert Occurrence
Encyclopedia of food sciences and nutrition, 2293-2296 (2003)
Lloyd Ryan et al.
The Journal of biological chemistry, 288(28), 20162-20172 (2013-06-06)
Antimicrobial or host defense peptides are innate immune regulators found in all multicellular organisms. Many of them fold into membrane-bound α-helices and function by causing cell wall disruption in microorganisms. Herein we probe the possibility and functional implications of antimicrobial
Lindsay M McMorran et al.
Journal of molecular biology, 425(17), 3178-3191 (2013-06-26)
Although many periplasmic folding factors have been identified, the mechanisms by which they interact with unfolded outer membrane proteins (OMPs) to promote correct folding and membrane insertion remain poorly understood. Here, we have investigated the effect of two chaperones, Skp
Carolina Medina Amado et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183135-183135 (2019-11-19)
The mechanism of action of the anti-Listeria peptide enterocin CRL35 was studied with biophysical tools by using lipid mixtures that mimicked Gram-positive plasma membranes. Langmuir monolayers and infrared spectroscopy indicated that the peptide readily interacted with phospholipid assembled in monolayers
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Articles

Critical Micelle Concentrations (CMCs) - Avanti Research™ Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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