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840419P

Avanti

16:0 Phosphatidylmethanol

1,2-dipalmitoyl-sn-glycero-3-phosphomethanol (sodium salt), powder

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Synonym(s):
1,2-dihexadecanoyl-sn-glycero-3-phosphomethanol (sodium salt)
Empirical Formula (Hill Notation):
C36H70O8PNa
CAS Number:
92609-89-7
Molecular Weight:
684.90
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (840419P-25mg)

manufacturer/tradename

Avanti Polar Lipids 840419P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C36H71O8P.Na/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-35(37)42-32-34(33-43-45(39,40)41-3)44-36(38)31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;/h34H,4-33H2,1-3H3,(H,39,40);/q;+1/p-1/t34-;/m1./s1

InChI key

JDEIVNUSWULHEB-MDYNBEAQSA-M

Application

16:0 Phosphatidylmethanol (1,2-dipalmitoyl-sn-glycero-3-phosphomethanol (sodium salt)) may be used as a standard in ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis for the quantification of phosphatidylethanols (PEths) in whole blood, venous/capillary-dried blood spots (V-DBS and C-DBS).

Biochem/physiol Actions

Phosphatidylmethanol is an anionic lipid which binds to the Phospholipase D. It is categorized as an alkyl phosphate lipid under headgroup modified lipids.

Packaging

5 mL Amber Glass Screw Cap Vial (840419P-25mg)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Stieglitz et al.
The Journal of biological chemistry, 274(50), 35367-35374 (1999-12-10)
The Streptomyces chromofuscus phospholipase D (PLD) cleavage of phosphatidylcholine in bilayers can be enhanced by the addition of the product phosphatidic acid (PA). Other anionic lipids such as phosphatidylinositol, oleic acid, or phosphatidylmethanol do not activate this PLD. This allosteric
Natalie Kummer et al.
Analytical and bioanalytical chemistry, 408(3), 825-838 (2015-11-26)
Phosphatidylethanol species (PEths) are promising biomarkers of alcohol consumption. Here, we report on the set-up, validation, and application of a novel UHPLC-ESI-MS/MS method for the quantification of PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 in whole blood (30 μL) and

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