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840053P

Avanti

Brain PC

Avanti Research™ - A Croda Brand 840053P, powder

Synonym(s):

L-α-phosphatidylcholine (Brain, Porcine)

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About This Item

CAS Number:
383907-52-6
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 2 × 100 mg (840053P-200mg)
pkg of 1 × 25 mg (840053P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840053P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C42H82NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h20-21,40H,6-19,22-39H2,1-5H3/b21-20-/t40-/m1/s1

InChI key

WTJKGGKOPKCXLL-VYOBOKEXSA-N

General description

Phosphatidylcholine (PC) is an important structural component of cell membrane and plasma lipoprotein. It is synthesized by CDP choline pathway. Liver is the main site for the synthesis of PC. Brain PC predominantly contains PC 16:0/16:0 and PC 16:0/18:1.

Application

Brain PC is suitable for use:
  • in the preparation of small unilamellar vesicles (SUVs)
  • as a constituent in serial protein misfolding cyclic amplification (sPMCA) buffer
  • as standard for ion mobility shift-mass spectrometry (IMS-MS)

Biochem/physiol Actions

Phosphatidylcholine (PC) is the major source of choline through food supplements. PC helps in improving learning and memory. PC functions in membrane fusion and transport and endocytosis. It is implicated in lowering of blood lipid and cholesterol levels, preventing cardiovascular disease and inhibiting obesity.

Packaging

5 mL Clear Glass Sealed Ampule (840053P-200mg)
5 mL Clear Glass Sealed Ampule (840053P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Requirements for mutant and wild-type prion protein misfolding in vitro.
Noble GP, et al.
Biochemistry, 54(5), 1180-1187 (2015)
Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine.
Zhou MM, et al.
Lipids in Health and Disease, 15(1), 135-135 (2016)
Choline, Phospholipids, Health, and Disease (1998)
The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver.
van der Veen JN, et al.
The Journal of Biological Chemistry, 287(28), 23418-23426 (2012)
Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins.
Methods in Cell Biology, 128, 223-241 (2015)
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