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840046P

Avanti

Brain PI(4,5)P2

Avanti Research™ - A Croda Brand

Synonym(s):

Brain PI(4,5)P2

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About This Item

CAS Number:
383907-42-4
NACRES:
NA.25
UNSPSC Code:
12352211

Key Documents

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Product Name

Brain PI(4,5)P2, Avanti Research™ - A Croda Brand

InChI

1S/C47H85O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)63-39(37-61-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-62-69(59,60)66-45-42(50)43(51)46(64-67(53,54)55)47(44(45)52)65-68(56,57)58;;;/h11,13,17,19,22,24,28,30,39,42-47,50-52H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,59,60)(H2,53,54,55)(H2,56,57,58);3*1H3/b13-11-,19-17-,24-22-,30-28-;;;/t39-,42?,43+,44?,45-,46?,47?;;;/m1.../s1

InChI key

GAIOWTITBYPFJE-JVILRMJCSA-N

SMILES string

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

description

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (840046P-1mg)
pkg of 1 × 10 mg (840046P-10mg)
pkg of 1 × 25 mg (840046P-25mg)
pkg of 1 × 5 mg (840046P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

Application

Brain PI(4,5)P2 has been used:
  • in the preparation of Folch liposome
  • in the preparation of giant unilamellar vesicles and multilamellar lipid sheets
  • as a substrate for rubidium flux assay
  • in the biochemical reaction assay mixture for various lipid kinases like Phosphatidylinositol-3-kinase gamma (PI3Kγ), Phosphatidylinositol-3-kinase beta (PI3Kβ), Phosphatidylinositol-3-kinase gamma (PI3Kα)

Biochem/physiol Actions

Phosphatidylinositol 4,5-bisphosphate (PIP2) is a signaling phospholipid, present in the plasma membrane. It acts as a precursor for inositide 3 phosphate, diacylglycerol. PIP2 is a gating ligand for most of the ion channels. It functions as an activatory ligand for eukaryotic inward rectifier potassium (Kir) channels.

General description

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Phosphatidylinositol 4,5-bisphosphate (PIP2) is synthesized from the precursor phosphatidylinositol 4-phosphate(PI4P). PIP2 is a phosphoinositide with three negative charges.

Packaging

5 mL Clear Glass Sealed Ampule (840046P-10mg)
5 mL Clear Glass Sealed Ampule (840046P-1mg)
5 mL Clear Glass Sealed Ampule (840046P-25mg)
5 mL Clear Glass Sealed Ampule (840046P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

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Structural dynamics of potassium-channel gating revealed by single-molecule FRET
Wang S, et al.
Nature Structural and Molecular Biology, 23(1), 31-31 (2016)
Regulation of ion channels by phosphatidylinositol 4, 5-bisphosphate
Suh BC and Hille B
Current Opinion in Neurobiology, 15(3), 370-378 (2005)
Friction mediates scission of tubular membranes scaffolded by BAR proteins
Simunovic M, et al.
Cell, 170(1), 172-184 (2017)
Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains
Boucrot E, et al.
Cell, 149(1), 124-136 (2012)
Rose E Dixon et al.
eLife, 4 (2015-02-26)
In the heart, reliable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple CaV1.2 channels. Yet the mechanisms that coordinate this simultaneous opening during every heartbeat are unclear.
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